青颖

助理研究员

学术经历

  • 2018年起，上海交通大学Bio-X研究院助理研究员。
  • 2016至2018年，上海交通大学Bio-X研究院博士后。

研究方向

精神疾病致病机理和生物标志物

基于体液代谢组与口腔、肠道微生物组，开发精神分裂症、抑郁症的诊断、预警与预后生物标志物，挖掘致病机理。

精神疾病烟酸皮肤表型

1. 多不饱和脂肪酸在精神分裂症、抑郁症烟酸皮肤反应钝化中的作用；

2. 烟酸皮肤反应及其代谢特征在儿童精神障碍中的变化规律，包括精神分裂症、抑郁症、双相情感障碍、孤独症谱系障碍和注意缺陷多动障碍等。

代表论著

  • •  

    1. Yang XH#, Li MH#, Jiang J#, Hu XW, Qing Y, Sun LY, Yang TQ, Wang DD, Cui GP, Gao Y, Zhang J, Li XW, Shen YH, Qin SY, Wan CL*. Dysregulation of phospholipase and cyclooxygenase expression is involved in Schizophrenia. Ebiomedicine. 2021;64.

    2. Li MH#, Yang XH#, Sun LY, Qing Y, Hu XW, Jiang J, Wang DD, Cui GP, Gao Y, Zhang E, Zhang J, Yang Y*, Wan CL*. Decreased serum apolipoprotein A4 as a potential peripheral biomarker for patients with schizophrenia. J Psychiatr Res. 2021;137:14-21.

    3. Wang DD#, Hu XW#, Jiang J, Sun LY, Qing Y, Yang XH, Gao Y, Cui GP, Li MH, Wang PK, Zhang J, Zhuang Y, Li ZZ, Li J, Guan LL, Zhang TH, Wang JJ, Ji F*, Wan CL*. Attenuated and delayed niacin skin flushing in schizophrenia and affective disorders: A potential clinical auxiliary diagnostic marker. Schizophr Res. 2021;230:53-60.

    4. Cui GP#, Qing Y#, Hu XW, Wang PK, Sun LY, Yang XH, Jiang J, Zhang J, Wang H, Feng L, Shen YH, Qin SY*, Wan CL*. Serum Metabolomic Profiling Based on Fourier Transform-Ion Cyclotron Resonance-Mass Spectrometry: Do the Dysfunctions of Metabolic Pathways Reveal a Universal Risk of Oxidative Stress in Schizophrenia? Antioxid Redox Sign. 2020;33:679-688.

    5. Xu CY, Yang XH, Sun LY, Yang TQ, Cai CQ, Wang P, Jiang J, Qing Y, Hu XW, Wang DD, Wang PK, Cui GP, Zhang J, Li Y, Feng J, Liu CX, Wan CL*. An investigation of calcium-independent phospholipase A2 (iPLA2) and cytosolic phospholipase A2 (cPLA2) in schizophrenia. Psychiat Res. 2019;273:782-787.

    6. Jiang J#, Peng C#, Sun LY, Li J, Qing Y, Hu XW, Yang XH, Li Y, Xu CY, Zhang J, Min J, Li XW, Qin SY, Lin M, Tan LW, Wan CL*. Leukocyte Proteomic Profiling in First-Episode Schizophrenia Patients: Does Oxidative Stress Play Central Roles in the Pathophysiology Network of Schizophrenia? Antioxid Redox Sign. 2019;31:579-588.

    7. Sun LY, Yang XH, Jiang J, Hu XW, Qing Y, Wang DD, Yang TQ, Yang C, Zhang J, Yang P, Wang P, Cai CQ, Wang JJ, He L, Wan CL*. Identification of the Niacin-Blunted Subgroup of Schizophrenia Patients from Mood Disorders and Healthy Individuals in Chinese Population. Schizophrenia Bull. 2018;44:896-907.

    8. Qing Y#, Sun LY#, Yang C, Jiang J, Yang XH, Hu XW, Cui DH, Xu YF, He L, Han DM, Wan CL*. Dysregulated 14-3-3 Family in Peripheral Blood Leukocytes of Patients with Schizophrenia. Sci Rep-Uk. 2016;6.

    9. Sun LY#, Qing Y#, Yang XH, Yang C, Jiang J, Hu XW, Ding JY, He L, Tan LW*, Wan CL*. Gene Expression Profiling of the xMHC Region Reveals 9 Candidate Genes in Schizophrenia. J Clin Psychiat. 2016;77:E597-U575.

    10. Qing Y, Yang JL, Wan CL*. Increased serum fibroblast growth factor 21 levels in patients with schizophrenia. Aust Nz J Psychiat. 2015;49:849-850.

    论文下载 支撑材料
    •  

    1. Yang XH#, Li MH#, Jiang J#, Hu XW, Qing Y, Sun LY, Yang TQ, Wang DD, Cui GP, Gao Y, Zhang J, Li XW, Shen YH, Qin SY, Wan CL*. Dysregulation of phospholipase and cyclooxygenase expression is involved in Schizophrenia. Ebiomedicine. 2021;64.

    2. Li MH#, Yang XH#, Sun LY, Qing Y, Hu XW, Jiang J, Wang DD, Cui GP, Gao Y, Zhang E, Zhang J, Yang Y*, Wan CL*. Decreased serum apolipoprotein A4 as a potential peripheral biomarker for patients with schizophrenia. J Psychiatr Res. 2021;137:14-21.

    3. Wang DD#, Hu XW#, Jiang J, Sun LY, Qing Y, Yang XH, Gao Y, Cui GP, Li MH, Wang PK, Zhang J, Zhuang Y, Li ZZ, Li J, Guan LL, Zhang TH, Wang JJ, Ji F*, Wan CL*. Attenuated and delayed niacin skin flushing in schizophrenia and affective disorders: A potential clinical auxiliary diagnostic marker. Schizophr Res. 2021;230:53-60.

    4. Cui GP#, Qing Y#, Hu XW, Wang PK, Sun LY, Yang XH, Jiang J, Zhang J, Wang H, Feng L, Shen YH, Qin SY*, Wan CL*. Serum Metabolomic Profiling Based on Fourier Transform-Ion Cyclotron Resonance-Mass Spectrometry: Do the Dysfunctions of Metabolic Pathways Reveal a Universal Risk of Oxidative Stress in Schizophrenia? Antioxid Redox Sign. 2020;33:679-688.

    5. Xu CY, Yang XH, Sun LY, Yang TQ, Cai CQ, Wang P, Jiang J, Qing Y, Hu XW, Wang DD, Wang PK, Cui GP, Zhang J, Li Y, Feng J, Liu CX, Wan CL*. An investigation of calcium-independent phospholipase A2 (iPLA2) and cytosolic phospholipase A2 (cPLA2) in schizophrenia. Psychiat Res. 2019;273:782-787.

    6. Jiang J#, Peng C#, Sun LY, Li J, Qing Y, Hu XW, Yang XH, Li Y, Xu CY, Zhang J, Min J, Li XW, Qin SY, Lin M, Tan LW, Wan CL*. Leukocyte Proteomic Profiling in First-Episode Schizophrenia Patients: Does Oxidative Stress Play Central Roles in the Pathophysiology Network of Schizophrenia? Antioxid Redox Sign. 2019;31:579-588.

    7. Sun LY, Yang XH, Jiang J, Hu XW, Qing Y, Wang DD, Yang TQ, Yang C, Zhang J, Yang P, Wang P, Cai CQ, Wang JJ, He L, Wan CL*. Identification of the Niacin-Blunted Subgroup of Schizophrenia Patients from Mood Disorders and Healthy Individuals in Chinese Population. Schizophrenia Bull. 2018;44:896-907.

    8. Qing Y#, Sun LY#, Yang C, Jiang J, Yang XH, Hu XW, Cui DH, Xu YF, He L, Han DM, Wan CL*. Dysregulated 14-3-3 Family in Peripheral Blood Leukocytes of Patients with Schizophrenia. Sci Rep-Uk. 2016;6.

    9. Sun LY#, Qing Y#, Yang XH, Yang C, Jiang J, Hu XW, Ding JY, He L, Tan LW*, Wan CL*. Gene Expression Profiling of the xMHC Region Reveals 9 Candidate Genes in Schizophrenia. J Clin Psychiat. 2016;77:E597-U575.

    10. Qing Y, Yang JL, Wan CL*. Increased serum fibroblast growth factor 21 levels in patients with schizophrenia. Aust Nz J Psychiat. 2015;49:849-850.

    论文下载 支撑材料
  • 安徽省卫生健康委员会，安徽省卫生健康委科研项目，AHWJ2021b157，青少年抑郁症多不饱和脂肪酸（PUFA）补充治疗的观察性研究，2021-01至2022-12，合作。
  • 上海市科学技术委员会，自然科学基金面上项目，20ZR1426700，肠道菌群与胆汁酸的互作在精神分裂症中的作用研究，2020-07至2023-06，主持。
  • 上海交通大学，“交大之星”计划医工交叉研究基金，青年项目A类，YG2019QNA03，基于药物代谢组学的环孢素肾毒性生物标志物体系模型的建立与验证研究，2020-01至2022-12，合作。
  • 上海交通大学，“交大之星”计划医工交叉研究基金，青年项目B类，YG2019QNB35，孕早期外周血B淋巴细胞比例及IgA抗体水平对妊娠期糖尿病诊断和治疗预测价值的临床研究，2020-01至2022-12，合作。
  • 上海交通大学，新进青年教师启动计划，19X100040033，肠道菌群与宿主共代谢在精神分裂症发生中的作用研究，2019-01至2021-12，主持。

承担项目