孔旭东

长聘教轨副教授

  • 电话:+86-021 6869 6004
  • 邮箱:xudong.kong@sjtu.edu.cn
  • 地址:上海市浦东新区张衡路429号,2号楼409室
  • 主要从事基于噬菌体展示的蛋白与多肽进化研究。获得国家海外高层次人才项目支持。在Nat Chem、Nat Biomed Eng、PNAS、Angew Chem Int Ed等刊物发表多篇研究论文。常年欢迎化学生物学、分子生物学、结构生物学等背景的博士后和研究生加盟。

学术经历

  • 2005-2009 华东理工大学生物工程专业 学士
  • 2009-2015 华东理工大学生物化工专业 博士(上海有机化学研究所联合培养)

                         导师:许建和教授,周佳海研究员

  • 2015-2020 洛桑联邦理工学院(EPFL) 博士后

                          合作导师:Prof. Christian Heinis

  • 2020-至今 上海交通大学 长聘教轨副教授 博导

研究方向

蛋白适应度地形分析

结合噬菌体展示技术和二代测序对蛋白的序列-结构-功能关系进行全局分析

口服多肽药物开发

聚焦多肽分子的稳定性和透膜性进化,开发靶向肠道疾病的口服多肽药物

代表论著

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    He, R.N., Zhang, M.J., Dai B.# and Kong, X.D.# Selection of Peptide−Bismuth Bicycles Using Phage Display. ACS Chem. Biol. 2024, doi: 10.1021/acschembio.4c00099

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    Sun, C.*, Ma, B.D.*, Li, G., Tian, W., Yang, L., Peng, H., Lin, Z., Deng, Z., Kong, X.D.# and Qu, X.# Engineering the substrate specificity of a P450 dimerase enables the collective biosynthesis of heterodimeric tryptophan-containing diketopiperazines. Angew Chem. Int. Ed., 2023, e202304994.

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    Kale, S.S.*, Villequey, C.*, Kong, X.D.*, Zorzi, A., Deyle, K., Heinis, C#. Cyclization of peptides with two chemical bridges affords large scaffold diversities. Nat. Chem., 2018, 10, 715-723.

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    Kale, S.S.*, Villequey, C.*, Kong, X.D.*, Zorzi, A., Deyle, K., Heinis, C#. Cyclization of peptides with two chemical bridges affords large scaffold diversities. Nat. Chem., 2018, 10, 715-723.

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    Kong, X.D., Moriya, J., Carle, V., Pojer, F., Abriata, L.A., Deyle, K., Heinis, C. De novo development of proteolytically resistant therapeutic peptides for oral administration. Nat. Biomed. Eng., 2020, 4, 560–571.

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    Kong, X.D., Carle, V., Díaz-Perlas, C., Butler, K., Heinis, C.# Generation of a large peptide phage display library by self-ligation of whole-plasmid PCR product. ACS Chem. Biol., 2020, 15, 2907–2915.

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    Kong, X.D., Yuan, S.G., Li, L., Chen, S., Xu, J.H.# and Zhou, J.# Engineering of an epoxide hydrolase for efficient bioresolution of bulky pharmaco substrates. Proc. Natl. Acad. Sci. USA, 2014, 111, 15717-15722.

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    Kong, X.D., Yuan, S.G., Li, L., Chen, S., Xu, J.H.# and Zhou, J.# Engineering of an epoxide hydrolase for efficient bioresolution of bulky pharmaco substrates. Proc. Natl. Acad. Sci. USA, 2014, 111, 15717-15722.

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    Kong, X.D., Ma, Q., Zhou, J.#, Zeng, B.B.# and Xu, J.H.# A smart library of epoxide hydrolase variants and the top hits for synthesis of (S)-beta-blocker precursors. Angew Chem. Int. Ed., 2014, 53, 6641-6644.