Yongchun Zhang

Tenure-track Associate Professor

  • Tel: +86-021
  • Email: yongchun_zhang@sjtu.edu.cn
  • Address: Shanghai Jiao tong University School of Life Sciences and Biotechnology, 800 Dongchun Road, Minhang, Shanghai 200240
  • Lab Web: https://zhangyongchun1.wixsite.com/zhanglab
  • We are using various approaches, including mouse genetics, 3D organoids, molecular technologies, and bioinformatics, to study stem cells, development, regeneration, and cancer in the esophagus. Google scholar profile (https://scholar.google.com/citations?user=l_4VHj8AAAAJ&hl=en)

Selected Publications

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    Yu Jiang#, Haidi Huang#, Jiangying Liu#, Dan Luo, Rongzi Mu, Jianghong Yuan, Jihong Lin, Qiyue Chen, Wufan Tao, Ling Yang, Man Zhang, Pingping Zhang, Fengqin Fang, Jianming Xu, Qingqiu Gong, Zhiping Xie, Yongchun Zhang*. Hippo cooperates with p53 to maintain foregut homeostasis and suppress the malignant transformation of foregut basal progenitor cells. 2024 PNAS. 121(10):e2320559121. (#co-first authors, *corresponding author)

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    Haidi Huang#, Yu Jiang#, Jiangying Liu, Dan Luo, Jianghong Yuan, Rongzi Mu, Xiang Yu, Donglei Sun, Jihong Lin, Qiyue Chen, Xinjing Li, Ming Jiang, Jianming Xu, Bo Chu, Chengqian Yin, Lei Zhang, Youqiong Ye, Bo Cao, Qiong Wang*, Yongchun Zhang*. Jag1/2 maintain esophageal homeostasis and suppress foregut tumorigenesis by restricting the basal progenitor cell pool. 2024 Nature Communications 15(1):4124. (#co-first authors, *corresponding author)

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    Yongchun Zhang, Ying Yang, Ming Jian g, Sarah Xuelian Huang, Wanwei Zhang, Denise Al Alam, Soula Danopoulos, Munemasa Mori, Ya-Wen Chen, Revathi Balasubramanian, Susan a M. Chuva de Sousa Lopes, Carlos Serra, Monika Bialecka, Eugene Kim, Sijie Lin, Ana Luisa Rodrigues Toste de Carvalho, Paul N. Riccio, Wellington V. Cardoso, Xin Zhang, Hans-Willem Snoeck, Jianwen Que. 3D Modeling of Esophageal Development using Human PSC-Derived Bas al Progenitors Reveals a Critical Role for Notch Signaling. 2018 Cell Stem Cell. 23(4):516-529. 

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    Yongchun Zhang, Jianwen Que. BMP signaling in development, stem cells, and diseases of the gastrointestinal tract. 2020 Annual Review of Physiology. 82:251-273.

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    Yongchun Zhang*, Dominique Bailey, Patrick Yang, Eugene Kim, Jianwen Que*. The development and stem cells of the esophagus. 2021 Development 148(6):dev193839. (*corresponding authors)

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    Dominique D Bailey#, Yongchun Zhang#, Benjamin J van Soldt#, Ming Jiang, Supriya Suresh, Hiroshi Nakagawa, Anil K Rustgi, Seema S Aceves, Wellington V Cardoso, Jianwen Que. Use of hPSC-derived 3D organoids and mouse genetics to define the roles of YAP in the development of the esophagus. 2019 Development 146(23):dev178855. (#co-first authors)

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    Yongchun Zhang, Ming Jiang, Eugene Kim, Sijie Lin, Kuancan Liu, Xiaopeng Lan, Jianwen Que. Development and stem cells of the esophagus. 2017 Seminars in Cell & Developmental Biology. 66, 25-35. 

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    Yongchun Zhang, Regis J O'Keefe, Jennifer H Jonason. BMP-TAK1 (MAP3K7) induces adipocyte differentiation through PPARγ signaling. 2017 Journal of Cellular Biochemistry 118 (1), 204-210. 

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    Yongchun Zhang, Tzong-jen Sheu, Donna Hoak, Jie Shen, Matthew J Hilton, Michael J Zuscik, Jennifer H Jonason, Regis J O'Keefe. CCN1 Regulates Chondrocyte Maturation and Cartilage Development. 2016 Journal of Bone and Mineral Research 31 (3), 549-559. 

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    Ming Jiang, Haiyan Li, Yongchun Zhang, Ying Yang, Rong Lu, Kuancan Liu, Sijie Lin, Xiaopeng Lan, Haikun Wang, Han Wu, Jian Zhu, Zhongren Zhou, Jianming Xu, Dong-Kee Lee, Lanjing Zhang, Yuan-Cho Lee, Jingsong Yuan, Julian A. Abrams, Timothy C. Wang, Antonia R. Sepulveda, Qi Wu, Huaiyong Chen, Xin Sun, Junjun She, Xiaoxin Chen, Jianwen Que. Transitional basal cells at the squamous-columnar junction generate Barrett's esophagus. 2017 Nature 26;550(7677):529-533.