Regulation and optimization of membrane protein structure and functions via rational design tools including the QTY code.
De novo protein design or the optimizations of functions and properties of proteins based on their primary sequences and 3D conformations, via generative models such as the diffusion model.
Elucidating molecular structures and mechanistic pathways of native membrane proteins through design method. Develop antibody-like decoy receptors as novel therapeutic agents.
R. Qing|*, M. Xue|, J. Zhao, L. Wu, A. Breitwieser, E. Smorodina, T. Schubert, G. Azzellino, D. Jin, J. Kong, T. Palacios*, U. Sleytr, S. Zhang*. “Scalable biomimetic sensing system with membrane receptor dual-monolayer probe and graphene transistor arrays”, Science Advances, 9, 29, (2023) eadf1402.
R. Qing*, S. Hao*, E. Smorodina, D. Jin, A. Zalevsky, S. Zhang*. “Protein Design: From the Aspect of Water Solubility”, Chemical Reviews, 122, 18, (2022) 14085-14179.
R. Meng, S. Hao*, C. Sun, Z. Hou, Y. Hou, L. Wang, P. Deng, P. Deng, J. Deng, Y. Yang, H. Xia, B. Wang*, R. Qing*, S. Zhang*. “Reverse-QTY code design of active human serum albumin self-assembled amphiphilic nanoparticles for effective anti-tumor drug doxorubicin release in mice”, Proceedings of the National Academy of Sciences, 120, 21, (2023) e2220173120.
R. Qing*, Q. Han, M. Skuhersky, M. Badr, H. Chung, T. Schubert, S. Zhang*. “QTY code designed thermostable and water-soluble chimeric chemokine receptors with tunable ligand affinity”, Proceedings of the National Academy of Sciences, 116-51, (2019) 25668-25676.
R. Qing|*, F. Tao|, P. Chatterjee|, G. Yang, Q. Han, H. Chung, J. Ni, B. Suter, J. Kubicek, B. Maertens, T. Schubert, C. Blackburn, S. Zhang*. “Non-full-length water-soluble CXCR4QTY and CCR5QTY chemokine receptors: implication for overlooked truncated but functional membrane receptors”, 23-12, iScience, (2020) 101670.
L. Chen, R. Meng, R. Qing, W. Li, Z. Wang, Y. Hou, J. Deng, W. Pu, Z. Gao, B. Wang, S. Hao*. “Bioinspired Robust Keratin Hydrogels for Biomedical Applications”, Nano Letters, 22, 22, (2022) 8835-8844.
S. Hao, D. Jin, S. Zhang*, R. Qing*. “QTY code designed water-soluble Fc-fusion cytokine receptors bind to their respective ligands”, QRB Discovery, 1-18, (2020).
P. Chatterjee*, N. Jakimo, J. Lee, N. Amrani, T. Rodriguez, S. Koseki, R. Qing, S. Hao, E. J. Sontheimer, J. M. Jacobson*. “An engineered ScCas9 with broad PAM range and high specificity and activity”, Nature Biotechnology, 38-10, (2020) 1212.
S. Zhang*, F. Tao, R. Qing, H. Tang, M. Skuhersky, K. Corin, L. Tegler, A. Wassie, B. Wassie, Y. Kwon, B. Suter, C. Entzian, T. Schubert, G. Yang, J. Labahn, J. Kubicek, B. Maertens. “QTY code enables design of detergent-free chemokine receptors that retain ligand-binding activities”, Proceedings of the National Academy of Sciences, 115-37, (2018) E8652-E8659.