Lingxin Kong

Assistant Researcher

  • Tel:
  • Email: konglingxin7@sjtu.edu.cn
  • Address:

Selected Publications

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    • Kong L, Wang Q, Yang W, Shen J, Li Y, Zheng X, Wang L, Chu Y, Deng Z, Chooi Y-H, You D.  Three recently diverging duplicated methyltransferases exhibit substrate-dependent regioselectivity essential for xantholipin biosynthesis. ACS Chem. Biol. 2020; 15(8): 2107-2115.

     

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    • Kong L, Wang Q, Deng Z, You D. Flavin adenine dinucleotide-dependent halogenase XanH and engineering of multifunctional fusion halogenases. Appl. Environ. Microbiol. 2020; 86(18).
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    • Kong L, Zhang W, Chooi YH, Wang L, Cao B, Deng Z, Chu Y, You D. A multifunctional monooxygenase XanO4 Catalyzes Xanthone Formation in xantholipin biosynthesis via a cryptic demethoxylation. Cell Chem.Biol. 2016, 23(4):508-516
       
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    Kong L, Liu J, Zheng X, Deng Z, You D. CtcS, a MarR family regulator, regulates chlortetracycline biosynthesis. BMC Microbiol, 2019, 2019:279.
     

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    Li J, Chen Y, Zheng T, Kong L, Zhu S, Sun Y, Deng, Yang L, You D. Quantitative mapping of DNA phosphorothioatome reveals phosphorothioate heterogeneity of low modification frequency, PLoS Genet. 2019, 15(4):e1008026.
     

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    Li Y, Kong L, Shen J, Wang Q, Liu Q, Yang W, Deng Z, You D. Characterization of the positive SARP family regulat or PieR for improving piericidin A1 production in Streptomyces piomogeues var. Hangzhouwanensis. Synth. Syst. Biotechnol. 2018, 4(1):16-24.
     

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    Shen J, Kong L, Li Y, Zheng X, Wang Q, Yang W, Deng Z, You D. A LuxR family transcriptional regulator AniF promotes the production of anisomycin and its derivatives in Streptomyces hygrospinosus var. beijingensis. Synth. Syst. Biotechnol. 2019,4(1):40-48.
     

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    Zhang C, Kong L, Liu Q, Lei X, Zhu T, Yin J, Lin B, Deng Z, You D. In Vitro characterization of echinomycin biosynthesis: formation and hydroxylation of L-tryptophanyl-S-enzyme and oxidation of (2S,3S) β-hydroxytryptophan. PLoS ONE. 2013. 8(2): e56772
     

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    Yang W, Kong L, Wang Q, Deng Z, You D. Metabolic engineering of a methyltransferase for production of drug precursors demecycline and demeclocycline in Streptomyces aureofaciensSynth. Syst. Biotechnol. 2020, 5(3):121-130.
     

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    Zhang W, Wang L, Kong L, Wang T, Chu Y, Deng Z, You D. Unveiling the post-PKS redox tailoring steps in biosynthesis of the type II polyketide antitumor antibiotic xantholipin. Chem. Biol. 2012,19(3):422-432