Our lab has broad interests in ecological and evolutionary genomics. Our research focuses on two main topics: structural variation (SV) and gene tree discordance (GTD). We combine experimental and computational approaches to investigate genome architectures of SV and GTD in corals and primates. We aim to understand how those architectures are associated with the origins of human genetic diseases and the adaptive evolution of corals and primates.
Mao, Y.*, Zhang, G. (2022) A complete, telomere-to-telomere human genome sequence presents new opportunities for evolutionary genomics. Nature Methods, 19, 635–638.
Mao, Y., Catacchio, C.R., Hillier, L.W., Porubsky, D., Li, R., Sulovari, A., ... & Eichler, E.E. (2021). A high-quality bonobo genome refines the analysis of hominid evolution. Nature, 594(7861), 77-81.
Yang, X., Wang, X., Zou, Y. ... Mao, Y.*. (2023). Characterization of large-scale genomic differences in the first complete human genome. Genome Biology, 24, 157.
Mao, Y.*, & Satoh, N. (2019). A likely ancient genome duplication in the speciose reef-building coral genus, Acropora. Iscience, 13, 20-32.