Yafei Mao

  • Tel: +86-021-62932151
  • Email: yafmao@sjtu.edu.cn
  • Address: Little White House, 1954 Huashan Road, Shanghai, 200030, China
  • Lab Web: https://www.yafmao.org/
  • Our lab has broad interests in evolution, genomics, and neurological diseases. We combine experimental and computational approaches to investigate (epi)genomic changes in primate evolution.

Research Interests

Evolutionary Genomics

Our lab has broad interests in ecological and evolutionary genomics. Our research focuses on two main topics: structural variation (SV) and gene tree discordance (GTD). We combine experimental and computational approaches to investigate genome architectures of SV and GTD in corals and primates. We aim to understand how those architectures are associated with the origins of human genetic diseases and the adaptive evolution of corals and primates.

Selected Publications

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    Mao, Y.*, Harvey, W. T., Porubsky, D., Munson, K. M., Hoekzema, K., Lewis, A. P., ... & Eichler, E. E.* (2024). Structurally divergent and recurrently mutated regions of primate genomes. Cell


    Mao, Y.*, Zhang, G. (2022) A complete, telomere-to-telomere human genome sequence presents new opportunities for evolutionary genomics. Nature Methods


    Mao, Y., Catacchio, C.R., Hillier, L.W., Porubsky, D., Li, R., Sulovari, A., ... & Eichler, E.E. (2021). A high-quality bonobo genome refines the analysis of hominid evolution. Nature


    Yang, X., Wang, X., Zou, Y. ... Mao, Y.*. (2023). Characterization of large-scale genomic differences in the first complete human genome. Genome Biology, 24, 157.


    Mao, Y.*, Economo, E.P., & Satoh, N. (2018). The roles of introgression and climate change in the rise to dominance of Acropora corals. Current Biology