Ya Guo

Tenure-track Associate Professor

  • Tel: +86-021-34204127
  • Email: guoya@sjtu.edu.cn
  • Address: Rm. 4A-411, Department of Genetics and Developmental Science, School of Life Sciences and Biotechnology, and Shanghai Pudong New Area People's Hospital, School of Medicine, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China
  • Group Leader, Omics and Artificial Intelligence. Our research integrates deep learning with 3D genomics, proteomics, and genome editing technologies to uncover the molecular mechanisms underlying 3D genome organization and gene regulation, and to understand how genomic variation shapes gene regulation and human disease.

Selected Publications

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    Zhu, Xinyi, et al. "3D chromosomal landscape reveals miR‐146a dysfunctional enhancer in lupus and establishes a CRISPR‐mediated approach to inhibit the IFN pathway." Arthritis & Rheumatology (2024).

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    Yin, Zihang, et al. "Identification of Two Subsets of Subcompartment A1 Associated with High Transcriptional Activity and Frequent Loop Extrusion." Biology 12.8 (2023): 1058.

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    Guo, Ya, et al. "Chromatin jets define the properties of cohesin-driven in vivo loop extrusion." Molecular Cell 82.20 (2022): 3769-3780.

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    Guo, Ya, et al. "CRISPR inversion of CTCF sites alters genome topology and enhancer/promoter function." Cell 162.4 (2015): 900-910.

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    Guo, Ya, et al. "CTCF/cohesin-mediated DNA looping is required for protocadherin α promoter choice." Proceedings of the National Academy of Sciences 109.51 (2012): 21081-21086.

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