张勇

副研究员

  • 电话:+8613122908236
  • 邮箱:yzhang2011@sjtu.edu.cn
  • 地址:Dongchuan Rd 800, Minhang Dist.
  • 实验室网址:https://enzyme.sjtu.edu.cn/en/
  • 从事酶结构功能及分子设计工作,主要使用国家同步辐射中心光源对蛋白晶体衍射,解析生物大分子的三维空间结构,联合生物化学及生物物理方法探索关键酶的催化机制。进而基于蛋白结构功能理解设计新功能酶及多酶级联催化体系,拓展生物催化的应用。

学术经历

  • 新疆大学学士,中国科学院上海药物研究所硕士,复旦大学分子遗传与生物化学博士,美国得克萨斯州大学奥斯汀分校博士后,美国密西根州立大学访问学者。现任上海交通大学副研究员,硕士生导师。

研究方向

新功能酶的挖掘,克隆与表征

新功能酶的挖掘,克隆与表征

蛋白结构解析,分子机制揭示

蛋白结构解析,分子机制揭示

酶分子设计/级联酶体系组装,抑制剂设计合成

酶分子设计/级联酶体系组装,抑制剂设计合成

代表论著

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    Yumeng Tan#, Yong Zhang#, Yunbin Han, Hao Liu, Haifeng Chen, Fuqiang Ma, Stephen G Withers, Yan Feng, Guangyu Yang* Directed evolution of an α1,3-fucosyltransferase using a single-cell  ultrahigh-throughput screening method. Science Advances, 2019,5 (10) eaaw8451 (# Contributed  equally)

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    Liuqing Chen, Qing Chang, Guangyu Yang, Yong Zhang*, Yan Feng* Structure of an Endogalactosylceramidase from Rhodococcus hoagii 103S Reveals the Molecular Basis of its Substrate Specificity. Journal of Structural Biology, 2019, 208(3)107393 (*Co-corresponding author)

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    Liang Yin, Xiang Guo, Lu Liu, Yong Zhang*, Yan Feng*. Self-Assembled Multimeric-Enzyme Nanoreactor for Robust and Efficient Biocatalysis. ACS Biomater. Sci. Eng., 2018, 4 (6), 2095–2099 (*Co-corresponding author)

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    Md Anarul Hoque#, Yong Zhang#, Liuqing Chen, Guangyu Yang, Mst Afroza Khatun, Haifeng Chen,Liu Hao, Yan Feng*, Stepwise Loop Insertion, Strategy for Active Site emodeling to Generate Novel Enzyme Functions. ACS Chem. Biol., 2017, 32(27)132-137(# Contributed equally)

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    Yong Zhang, Jiao An, Guangyu Yang, Xiaofei Zhang, Yuan Xie, Liuqing Chen, Yan Feng*. Structure features of GH10 xylanase from Caldicellulosiruptor bescii: implication for its thermophilic adaption and substrate binding preference. Acata Bioch. Bioph. Sin., 2016, 56(7). 56-67

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    Yong Zhang; Jian Bao; Xinxian Deng; Wan He; Jiajun Fan; Lei Fu*. Synthesis, biological evaluation and molecular docking of 2-phenyl- benzo[d] oxazole- 7-carboxamide derivatives as potential Staphylococcus aureus sortaseA inhibitors. Bioorg Med Chm Lett., 2016, 34(3). 21-28

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    Wan He#, Yong Zhang#, Jian Bao, Xinxian Deng, Jennifer Batara,Shawn Casey, Faqin Jiang*, Lei Fu*, Synthesis, biological evaluation and molecular docking analysis of 2-phenyl-benzofuran-3-carboxamide as a potential inhibitors of Sortase A. Bioorg & Med Chem. , 2016, 217(25)1341~1351 (# Contributed equally)

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    Ang Li, Yong Zhang*, Che Wang, Geng Wu*,Zhenchun Wang, Purification, molecular cloning, and antimicrobial activity of peptides from the skin secretion of the black-spotted frog, Rana nigromaculata. World J. Microbiol. Biotechnol., 2013, 32(2): 401-19 (*Co-corresponding author)

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    Seema Irani, Joshua Mayfield, Yong Zhang, Wendy L. Matthews and Yan Jessie Zhang*,Structure of S. cerevisiae Rtr1 reveals an atypical phosphatase with novel reaction mechanism, Sci. Signal., 2016, 9(417)

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    Yong Zhang, Mengmeng Zhang and Yan Zhang*. Crystal structure of Ssu72, an essential eukaryotic phosphatase specific for the C-terminal domain of RNA polymerase II, in complex with a transition state analogue. Biochem J., 2011, 434(3):435-44.

获奖情况

  • 2019年获江苏省扬中创新人才“江雁计划”

教学情况

  • 2018-2019-1 高级生物化学(研究生课程);
  • 2016-2017-1  生物大分子结构与功能(研究生课程);
  • 2015-2016-1  生物大分子结构与功能(研究生课程);
  • 2015-2016-1  蛋白质工程与应用 (本科生课程)
  • 国家自然科学基金面上基金:糖基转移酶UGT51底物选择性机制解析及分子再设计;2018/1-2021/12
  • 国家重点研发计划“蓝色粮仓科技创新”子课题:基于水产复杂底物的多酶级联及反应分离耦合关键技术; 2020/1-2022/12
  • 国家自然科学基金青年基金:糖基转移酶CgtB底物特异性改造及机理研究;2013/1-2015/12
  • 国家重点研发计划,中美国际合作项目“酰基修饰药物关键酶系的分子设计与药物创新优产”,2018/1-2019/12(参加)
  • 国家自然科学基金重点国际合作研究项目,中加国际合作“假糖类药物生物合成途径的全新构建及多重适配性机制研究”,2017/1-2021/12(参加)

承担项目

学生培养

  • 在读学生