章永春

长聘教轨副教授

  • 电话:+86-021
  • 邮箱:yongchun_zhang@sjtu.edu.cn
  • 地址:上海市东川路800号, 上海交通大学生命科学技术学院https://orcid.org/0009-0009-9949-0604; https://scholar.google.com/citations?user=l_4VHj8AAAAJ&hl=en
  • 博士生导师,独立课题组长,上海市海外高层次人才计划,主持国家和省部级自然科学基金面上项目。利用3D类器官、转基因小鼠、生化和分子手段研究消化道和呼吸道发育稳态、干细胞、再生和癌症。论文发表于Cell Stem Cell、PNAS、Sci Adv、Nat Commun等。

学术经历

教育和研究经历

  • 2020-今 上海交通大学生命科学技术学院,长聘教轨副教授,硕士和博士生导师
  • 2018-2019 美国哥伦比亚大学Columbia University,Associate Research Scientist
  • 2015-2018 美国哥伦比亚大学Columbia University,博士后
  • 2010-2015 美国罗彻斯特大学University of Rochester,博士
  • 2006-2010 南开大学生命科学学院,学士

研究方向

消化道(包括食管、胃和肠)的干细胞、肿瘤和类器官

1)消化道3D类器官的建立;

2)消化道肿瘤的形成与治疗研究;

3)人诱导多能干细胞分化和器官再生;

4)器官发育的分子和细胞调节机制

代表论著

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    Yu Jiang#, Haidi Huang#, Jiangying Liu#, Dan Luo, Rongzi Mu, Jianghong Yuan, Jihong Lin, Qiyue Chen, Wufan Tao, Ling Yang, Man Zhang, Pingping Zhang, Fengqin Fang, Jianming Xu, Qingqiu Gong, Zhiping Xie, Yongchun Zhang*. Hippo cooperates with p53 to maintain foregut homeostasis and suppress the malignant transformation of foregut basal progenitor cells. 2024 PNAS. 121(10):e2320559121. (#co-first authors, *corresponding author)

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    Haidi Huang#, Yu Jiang#, Jiangying Liu, Dan Luo, Jianghong Yuan, Rongzi Mu, Xiang Yu, Donglei Sun, Jihong Lin, Qiyue Chen, Xinjing Li, Ming Jiang, Jianming Xu, Bo Chu, Chengqian Yin, Lei Zhang, Youqiong Ye, Bo Cao, Qiong Wang*, Yongchun Zhang*. Jag1/2 maintain esophageal homeostasis and suppress foregut tumorigenesis by restricting the basal progenitor cell pool. 2024 Nature Communications. 15(1):4124. (#co-first authors, *corresponding author)

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    Yongchun Zhang#,*, Dimitris Karagiannis#, Helu Liu#, Mi Lin, Yinshan Fang, Ming Jiang, Xiao Chen, Supriya Suresh, Haidi Huang, Junjun She, Feiyu Shi, Jiangying Liu, Dan Luo, J. Carlos Angel, Guangtan Lin, Patrick Yang, Wael El-Rifai, Alexander Zaika, Anthony E. Oro, Anil K. Rustgi, Timothy C. Wang, Chao Lu*, Jianwen Que*. Epigenetic regulation of p63 blocks squamous-to-neuroendocrine transdifferentiation in esophageal development and malignancy. 2024 Science Advances. 10(41):eadq0479.  (#co-first authors, *corresponding authors)

     

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    Bingnan Zhao#, Xiuwei Yu#, Jintong Shi#, Shuangyu Ma#, Shizhao Li#, Haitao Shi, Shoubing Xia, Youqiong Ye, Yongchun Zhang*, Yanhua Du*, Qiong Wang*. A stepwise mode of TGFβ-SMAD signaling and DNA methylation regulates naïve-to-primed pluripotency and differentiation. 2024 Nature Communications. 22;15(1):10123. (#co-first authors, *corresponding authors)

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    Jiangying Liu#, Dan Luo#, Haidi Huang, Rongzi Mu, Jianghong Yuan, Ming Jiang, Chuwen Lin, Honggang Xiang, Xinhua Lin, Haihan Song, Yongchun Zhang*. Hippo cooperates with p53 to regulate lung airway mucous cell metaplasia. 2024 Disease Models & Mechanisms. 17(11):dmm052074. (#co-first authors, *corresponding author)

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    Yongchun Zhang, Ying Yang, Ming Jian g, Sarah Xuelian Huang, Wanwei Zhang, Denise Al Alam, Soula Danopoulos, Munemasa Mori, Ya-Wen Chen, Revathi Balasubramanian, Susan a M. Chuva de Sousa Lopes, Carlos Serra, Monika Bialecka, Eugene Kim, Sijie Lin, Ana Luisa Rodrigues Toste de Carvalho, Paul N. Riccio, Wellington V. Cardoso, Xin Zhang, Hans-Willem Snoeck, Jianwen Que. 3D Modeling of Esophageal Development using Human PSC-Derived Bas al Progenitors Reveals a Critical Role for Notch Signaling. 2018 Cell Stem Cell. 23(4):516-529. 

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    Yongchun Zhang, Jianwen Que. BMP signaling in development, stem cells, and diseases of the gastrointestinal tract. 2020 Annual Review of Physiology. 82:251-273.

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    Yongchun Zhang*, Dominique Bailey, Patrick Yang, Eugene Kim, Jianwen Que*. The development and stem cells of the esophagus. 2021 Development 148(6):dev193839. (*corresponding authors)

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    Yongchun Zhang, Ming Jiang, Eugene Kim, Sijie Lin, Kuancan Liu, Xiaopeng Lan, Jianwen Que. Development and stem cells of the esophagus. 2017 Seminars in Cell & Developmental Biology. 66, 25-35. 

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    Dominique D Bailey#, Yongchun Zhang#, Benjamin J van Soldt#, Ming Jiang, Supriya Suresh, Hiroshi Nakagawa, Anil K Rustgi, Seema S Aceves, Wellington V Cardoso, Jianwen Que. Use of hPSC-derived 3D organoids and mouse genetics to define the roles of YAP in the development of the esophagus. 2019 Development 146(23):dev178855. (#co-first authors)