副研究员
心血管病是危害人类生命健康最严重的疾病之一，其患病率和死亡率均居各类疾病之首。心血管病包括高血压、动脉粥样硬化、脑卒中和心肌梗塞等，这些心血管病都有共同的发病学基础和基本的病理过程，表现为心血管细胞迁移、肥大、增殖和凋亡等，具有细胞表型、形态结构与功能的改变，即发生血管重建。本实验室研究要从基因－蛋白－细胞－器官－整体不同层次上综合探讨血管重建机制，研究心血管力学信号转导通路与血管活性物质的功能及其分子网络调控机制。近年来，我更关注非编码RNA在高血压和静脉移植等疾病模型中的作用。
Yao QP, Liu Z, Yao AH, Liu JT, Jiang J, Chen Y, Li SS, Han Y, Jiang ZL, Qi YX*. Circular RNA CircTET3 mediates rat vascular smooth muscle cell migration by targeting miR-351-5p, Journal of Cellular Physiology, 2020; doi: 10.1002/jcp.29577
Xie ZW, Chen YX, Long CF, Qi YX, Yao QP*. Cyclic stretch induces VEGFA alternative splicing via Serine/Arginine-Rich Splicing Factor 1.Cell Mol Biol (Noisy-le-grand). 2018; 64(7):43-50.
Bao H, Chen YX, Huang K, Zhuang F, Bao M, Han Y, Chen XH, Shi Q, Yao QP*, Qi YX*. Platelet-derived microparticles promote endothelial cell proliferation in hypertension via miR-142-3p. FASEB J. 2018; 32(7):3912-3923.
Qing-Ping Yao, Zhiwei Xie, Kaixuan Wang, Ping Zhang, Yue Han, Ying-Xin Qi*, Jiang Zong-Lai. Profiles of lncRNAs in Hypertensive Rats: Long non-coding RNA XR007793 Regulates Cyclic Stretch-induced Vascular Smooth Muscle Cell Proliferation and Migration. Journal of hypertension, 2017; 35(6):1195-1203.
Qing-Ping Yao#, Ying-Xin Qi#, Ping Zhang, Bin-Bin Cheng, Zhi-Qiang Yan*, Zong-Lai Jiang. SIRT1 and Connexin40 Mediate the Normal Shear Stress-Induced Inhibition of the Proliferation of Endothelial Cells Co-Cultured with Vascular Smooth Muscle Cells. Cellular Physiology and Biochemistry, 2013; 31(2-3):389-399.
Yao QP, Hayman DM, Dai Q, Lindsey ML, Han HC, Alteration of Pulse Pressure Stimulates Arterial Wall Matrix Remodeling, Journal of Biomechanical Engineering. 2009; 131(10):101011.
Shi Q, Zhuang F, Liu JT, Li N, Chen YX, Su XB, Yao AH, Yao QP, Han Y, Li SS, Qi YX* & Jiang ZL. Single-cell analyses reveal functional classification of DCs and their potential roles in inflammatory disease. FASEB Journal. 2018, doi:10.1096/fj.20101489R.
Kai Huang, Han Bao, Zhi-Qiang Yan, Lu Wang, Ping Zhang, Qing-Ping Yao, Qian Shi, Xiao-Hu Chen, Kai-XuanWang, Bao-Rong Shen, Ying-Xin Qi*, and Zong-Lai Jiang . MicroRNA-33 protects against neointimal hyperplasia induced by arterial mechanical stretch in the graft vein. Cardiovascular Research. 2017; 113(5):488-497.
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