副研究员
1. 研究微生物代谢途径或产物如何通过影响人体代谢物水平、刺激人体免疫调节等机制影响宿主生理功能。
2. 研究微生物代谢产物在疾病诊断、预防和治疗中的潜在应用，如通过益生菌等干预手段改善宿主健康。
利用合成生物学、代谢工程等多种技术实现微生物合成多种高价值天然产物，并提升其产量。
Liu R, Luo Z, Dai C, Wei Y, Yan S, Kuang X, Qi K, Fu A, Li Y, Fu S, Ma Z, Dai W, Xiao X, Wu Q, Zhou H, Rao Y, Yuan J, Shi T, Deng Z*, Chen C*, Liu T*. Corynebacterium parakroppenstedtii secretes a novel glycolipid to promote the development of granulomatous lobular mastitis. Signal Transduction and Targeted Therapy. 2024, 9(1):292.
Yan P#, Wang G#, Huang M#, Liu Z, Dai C, Hu B, Gu M, Deng Z, Liu R*, Wang X*, Liu T*. Combinatorial Biosynthesis Creates a Novel Aglycone Polyether with High Potency and Low Side Effects Against Bladder Cancer. Advanced Science. 2024, 11(32):e2404668.
Li D#, Liu R#, Wang M#, Peng R#, Fu S, Fu A, Le J, Yao Q, Yuan T, Chi H, Mu X, Sun T, Liu H, Yan P, Wang S, Cheng S, Deng Z, Liu Z*, Wang G*, Li Y*, Liu T*.3β-Hydroxysteroid dehydrogenase expressed by gut microbes degrades testosterone and is linked to depression in males. Cell Host & Microbe. 2022, 9;30(3):329-339
Liu R, Zhang Y, Zhai G, Fu S, Xia Y, Hu B, Cai X, Zhang Y, Li Y, Deng Z, Liu T*. A cell-free platform based on nisin biosynthesis for discovering novel lanthipeptides and guiding their overproduction in vivo. Advanced Science. 2020, 7(17):2001616.
Mu X, Lei R, Yan S, Liu R*, Liu T*. The LysR family transcriptional regulator ORF-L16 regulates spinosad biosynthesis in Saccharopolyspora spinosa. Synthetic and Systems Biotechnology. 2024, 9 (4): 609-617
An Z#, Tao H#, Wang Y, Xia B, Zou Y, Fu S, Fang F, Sun X, Huang R, Xia Y, Deng Z, Liu R*, Liu T*. Increasing the heterologous production of spinosad in Streptomyces albus J1074 by regulating biosynthesis of its polyketide skeleton.Synthetic and Systems Biotechnology. 2021, 6(4):292-301.
Liu R#, Yu D#, Deng Z, Liu T*. Harnessing in vitro platforms for natural product research: in vitro driven rational engineering and mining (iDREAM). Current Opinion in Biotechnology. 2021, 69:1-9.
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