研究员
非2-酮糖是一类独特的稀有糖类，能用于合成其它药物的基本出发原料。不同于一般的2-酮糖如：果糖、木酮糖、山梨糖、核酮糖等糖类，非2-酮糖是多元醇（对于六元醇而言）的第3位或者第4位羟基被氧化为酮基的一类酮糖，若对于五元醇，其第3位羟基被氧化为3-酮糖。研究氧化醋酸杆菌的膜结合的酶催化多元醇生成非2-酮糖的机理，有助于我们开发合成3-酮糖或者4-酮糖的新的酶学方法。
解脂耶氏酵母具有丰富的合成其它功能化合物的途径，充分挖掘利用这些途径能高效合成其它的功能化合物，比如木糖醇、大麻素、甜菊糖苷等。我们正集中研究力量进行这些功能化合物的研究。
通过对解脂耶氏酵母基因组、代谢组的研究，提高该酵母合成甘露醇的转化率，阻断副产物合成途径，阻断利用甘露醇的途径，提高其耐高温发酵性能（如在35度下进行发酵），构建合成甘露醇的“超级菌株”。
通过对解脂耶氏酵母基因组、代谢组的研究，提高该酵母合成赤藓糖醇的转化率，阻断副产物合成途径，阻断利用赤藓糖醇的途径，提高其耐高温发酵性能（如在35度下进行发酵），构建合成赤藓糖醇的“超级菌株”。
Zhang L, An J, Li L, Wang H, Liu D, Li N, Cheng HR, Deng Z. Highly Efficient Fructooligosaccharides Production by an Erythritol-Producing Yeast Yarrowialipolytica Displaying Fructosyltransferase. J Agric Food Chem.2016,18,64(19):3828-37.（通讯作者）。
An J, Zhang L, Li L, Liu D, Cheng H, Wang H, Nawaz MZ, Cheng HR*, Deng Z. An Alternative Approach to Synthesizing Galactooligosaccharides by Cell-Surface Display of β-Galactosidase on Yarrowia lipolytica. J Agric Food Chem.2016,18,64(19):3819-27.（通讯作者）
Wang H, Li L, Zhang L, An J, Cheng HR*, Deng Z. Xylitol production from waste xylose mother liquor containing miscellaneous sugars and inhibitors: one-pot biotransformation byCandida tropicalisand recombinantBacillus subtilis.Microb Cell Fact.2016,16,15(1):82.（通讯作者）
Ning Li, Hengwei Wang, Huilin Cheng, Dawen Liu, Hairong Cheng*, Zixin Deng. An Integrated Approach to Producing High-purity Trehalose from Maltose by the YeastYarrowialipolyticaDisplaying Trehalose Synthase (TreS) on the Cell Surface.J. Agric. Food Chem.,2016,64(31), pp 6179–6187（通讯作者）
Siqi Wang, Hengwei Wang, JiyangLv, Zixin Deng, Hairong Cheng. Highly Efficient Erythritol Recovery from Waste Erythritol Mother Liquid by Yeast-mediated Biopurification. J. Agric. Food Chem.,2017,65:11020-11028.（通讯作者）
Huiling Cheng, Siqi Wang, Muhammad Bilal, Xuemei Ge, Can Zhang, Patrick Fickers and Hairong Cheng*. Identification, characterization of two NADPH-dependent erythrose reductases in the yeast Yarrowia lipolytica and improvement of erythritol productivity using metabolic engineering. Microbial Cell Factories, 2018,17:133. (通讯作者)
Ping Chi, Siqi Wang, Xuemei Ge, Muhammad Bilal, Patrick Fickers, Hairong Cheng*. Efficient D-threitol production by an engineered strain of Yarrowia lipolytica overexpressing xylitol dehydrogenase gene from Scheffersomyces stipitis. Biochemical Engineering Journal, 2019, 149 ,107259. (通讯作者)。
Producing Trehalose from Maltodextrin by the Erythritol-Producing Yeast Yarrowia lipolytica Co-displaying maltooligosyltrehalose synthase and maltooligosyltrehalose trehalohydrolase
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