钱志刚

副研究员

  • 电话:+86-021-34207248
  • 邮箱:zgqian@sjtu.edu.cn

学术经历

  • 2001年7月毕业于华东理工大学,获得生物化学工程专业学士学位。
  • 2004年3月毕业于华东理工大学,获得生物化工硕士学位。
  • 2009 年8月毕业于韩国科学技术院(KAIST),获得生命化学工学科博士学位。
  • 2009年8月至2010年8月在Sang Yup Lee教授实验室从事博士后工作,继续研究微生物系统代谢工程生物合成化学品和蛋白材料。
  • 2010 年11月至2012 年4月在美国波士顿大学生物医学工程系进行博士后研究,合作导师为James J. Collins教授,主要研究合成生态系统。
  • 2012年5月回国任上海交通大学生命科学技术学院副研究员。
  • 主要从事蛋白质工程、系统代谢工程与合成生物学的交叉学科研究。在包括PANS 等重要国际学术刊物上发表研究论文13篇。所发表的论文被选为Nature 杂志的Research Highlight,Nature Chemical Biology杂志的News and Views,Biotechnology and Bioengineering杂志的封面、亮点文章和Editors’Choice。申请或获得发明专利12项,其中包括3项国际专利。

代表论著

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    Xia XX, Qian ZG, Lee SY. 2011. Comparative proteomic and genetic analyses reveal unidentified mutations in Escherichia coli XL1-Blue and DH5α. FEMS Microbiol Lett 314(2):119-124.

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    Qian ZG, Xia XX, Lee SY. 2011. Metabolic engineering of Escherichia coli for the production of cadaverine: A five carbon diamine. Biotechnol Bioeng 108(1): 93-103.

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    Xia XX*, Qian ZG*, Ki, CS, Park, YH, Kaplan, DL, Lee SY. 2010. Native-sized recombinant spider silk protein produced in metabolically engineered Escherichia coli results in a strong fiber. Proc Natl Acad Sci USA 107(32):14059-14063. (Xia and Qian contributed equally).
    News and Views in Nature Chemical Biology (Linke WA. Biomaterials: Spider strength and stretchability. Nature Chemical Biology 6:702-703; October 2010)
    Featured by MIT Technology Review (3 August 2010)
    Featured by TCE Today (September 2010)

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    Qian ZG, Xia XX, Lee SY. 2009. Metabolic engineering of Escherichia coli for the production of putrescine: A four carbon diamine. Biotechnol Bioeng 104(4):651-662. Editors' Choice, Journal cover paper
    Wiley-Blackwell Press Release ‘Pioneering research succeeds in producing industrially vital chemical through engineered bacteria’ (27 August 2009); in numerous science news web sites
    Nature Research Highlight ‘Bacterial factories’ (Nature 461:14-15; 3 September 2009)
    BTJ-FORUM ‘Metabolic engineering of E. coli’ (Biotechnology Journal, 4:1376; October 2009)
    Top 25 Most Downloaded Articles From September-December 2009 (http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1097-0290/homepage/most_accessed_2009.htm)

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    Qian ZG, Xia XX, Choi JH, Lee SY. 2008. Proteome-based identification of fusion partner for high-level extracellular production of recombinant proteins in Escherichia coli. Biotechnol Bioeng 101(3):587-601.
    Spotlight ‘A proteome-based approach to identifying fusion partner for recombinant protein excretion’ (Biotechnology and Bioengineering DOI: 10.1002/bit.22096; 15 October 2008)

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    Xu Y, Zhao Z, Qian X, Qian Z, Tian W, Zhong J. 2006. Novel, unnatural benzo-1,2,3-thiadiazole-7-carboxylate elicitors of taxoid biosynthesis. J Agric Food Chem 54(23):8793-8798.

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    Qian ZG, Zhao ZJ, Xu Y, Qian X, Zhong JJ. 2006. Novel synthetic 2,6-dichloroisonicotinate derivatives as effective elicitors for inducing the biosynthesis of plant secondary metabolites. Appl Microbiol Biotechnol 71(2):164-167.

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    Qian ZG, Zhao ZJ, Xu Y, Qian X, Zhong JJ. 2006. Novel chemically synthesized salicylate derivative as an effective elicitor for inducing the biosynthesis of plant secondary metabolites. Biotechnol Prog 22(1):331-333.

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    Qian ZG, Zhao ZJ, Xu Y, Qian X, Zhong JJ. 2005. A novel synthetic fluoro-containing jasmonate derivative acts as a chemical inducing signal for plant secondary metabolism. Appl Microbiol Biotechnol 68(1):98-103.

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    Qian ZG, Zhao ZJ, Xu Y, Qian X, Zhong JJ. 2005. Highly efficient strategy for enhancing taxoid production by repeated elicitation with a newly synthesized jasmonate in fed-batch cultivation of Taxus chinensis cells. Biotechnol Bioeng 90(4):516-521.