副研究员
天然产物是药物的重要来源，本课题组聚焦于复杂活性天然产物（当前主要集中在聚酮和核苷类抗生素）的生物合成。综合生物催化，结构生物学，酶工程，合成生物学等多学科技术手段，对复杂微生物天然产物的生物合成展开研究，并揭示其中蕴含的新功能酶的催化机制；在了解生物合成途径的基础上尝试对其进行改造以获得结构改变活性更好的化合物结构，为发现和研制生物药物先导化合物奠定物质基础。
O-methyltransferase-like enzyme catalyzed diazo installation in polyketide biosynthesis. Zhao Y, Liu X, Xiao Z, Zhou J, Song X, Wang X, Hu L, Wang Y, Sun P, Wang W, He X, Lin S, Deng Z, Pan L, Jiang M. Nat Commun. 2023, 14(1):5372.
Importance of aspartic acid side chain carboxylate-arginine interaction in substrate selection of arginine 2,3-aminomutase BlsG. Luo X, Wang X, Zhang L, Du A, Deng Z , Jiang M*, He X*, Protein Sci. 2023, 32(3):e4584.
Unexpected Role of a short-chain dehydrogenase/reductase family protein in type II polyketide biosynthesis. Gao Y, Zhao Y, Zhou J, Yang M, Lin L, Wang W, Tao M, Deng Z, Jiang M, Angew Chem Int Ed Engl. 2022, 61(7): e202110445.
A [3Fe-4S] cluster and tRNA-dependent aminoacyltransferase BlsK in the biosynthesis of Blasticidin S. Wang X, Zhao Y, Gao Y, Luo X, Du A, Deng Z, Zabriskie TM, He X, Jiang M. Proc Natl Acad Sci U S A. 2021, 118(30): e2102318118.
Offloading role of a discrete thioesterase in type II polyketide biosynthesis. Hua K, Liu X, Zhao Y, Gao Y, Pan L, Zhang H, Deng Z, Jiang M. mBio. 2020, 11(5):e01334-20.
Heterologous Biosynthesis of Type II Polyketide Products Using E. coli. Liu X, Hua K, Liu D, Wu ZL, Wang Y, Zhang H, Deng Z, Pfeifer BA, Jiang M. ACS Chem Biol. 2020 May 15;15(5):1177-1183.
Liu X, Liu D, Xu M, Tao M, Bai L, Deng Z, Pfeifer BA, Jiang M. Reconstitution of kinamycin biosynthesis within the heterologous host streptomyces albus J1074, J Nat Prod., 2018, 81(1): 72~77.
Gao G, Liu X, Xu M, Wang Y, Zhang F, Xu L, Lv J, Long Q, Kang Q, Ou HY, Wang Y, Rohr J, Deng Z, Jiang M*, Lin S*, Tao M*. Formation of an angular aromatic polyketide from a linear anthrene precursor via oxidative rearrangement. Cell Chem Biol. 2017, 24(7):881-891.
科技部重点研发项目，放线菌底盘与异源途径适配性优化，2020-2024。
上海交通大学科技创新专项,聚酮类天然产物的生物合成机制研究，2016-2018。
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