副研究员
Develop and apply genome engineering tools to discover the genetic determinants for chassis cell construction regarding efficient biomanufacturing.
Develop genome engineering tools and smart response systems in mushroom for applicatons in efficient biosynthesis of secondary metabolites.
Wei Yuan, Chenjian Jiang, Qin Wang, Yubo Fang, Jin Wang, Meng Wang* and Han Xiao* (2022). Biosynthesis of mushroom-derived type II ganoderic acids by engineered yeast. Nat Commun, 13: 7740.
Yuhuan Luo, Zeqian Du, Chenjian Jiang, Ziqian Yu, Jian-Jiang Zhong*, Ting Shi* and Han Xiao* (2023). Rational engineering of a membrane-anchored promiscuous cytochrome P450 for efficient biosynthesis of valuable ganoderic acids. ACS Catal, 13: 15673-15681.
Yubo Fang and Han Xiao* (2022). The aspartic protease Yps3p and cell wall glucanase Scw10p are novel determinants that enhance the secretion of the anti-tumor triterpenoid GA-HLDOA in Saccharomyces cerevisiae. ACS Synth Biol, 11(9):2917-2926.
Chen Zhao, Qin Wang, Shaozhong Chang, Shuo Zhang, Zhonghua Li, Zihan Shen, Xin Jin, Han Xiao* and Huigang Zhang* (2022). Efficient transport system of cultivated mushroom mycelium enables its derived carbon with high performance electrochemical desalination capability. Carbon, 196: 699-707.
Xiaoting Lan, Wei Yuan, Meng Wang* and Han Xiao* (2019). Efficient biosynthesis of antitumor ganoderic acid HLDOA using a dual tunable system for optimizing the expression of CYP5150L8 and a Ganoderma P450 reductase. Biotechnol Bioeng, 116(12): 3301-3311.
Wen-Fang Wang, Han Xiao* (co-first author) and Jian-Jiang Zhong* (2018). Biosynthesis of a ganoderic acid in Saccharomyces cerevisiae by expressing a cytochrome P450 gene from Ganoderma lucidum. Biotechnol Bioeng, 115(7): 1842-1854.
Zehua Bao, Mohammad HamediRad, Pu Xue, Han Xiao, Ipek Tasan, Ran Chao, Jing Liang and Huimin Zhao* (2018). Genome-scale engineering of Saccharomyces cerevisiae with single nucleotide precision. Nature Biotechnol, 36(6): 505-508.
Pingan Wang, Han Xiao* and Jian-Jiang Zhong* (2020). CRISPR-Cas9 assisted functional gene editing in the mushroom Ganoderma lucidum. Appl Microbiol Biotechnol, 104: 1661-1671.
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