Yao Qian#, Jinmin Gao#, Ming Chen, Bo Pang, Zhijun Tang, Wei Huang, Wen Liu*. Analysis of siderochelin biosynthesis reveals that a type II polyketide synthase catalyses diketide formation. Nature Synthesis 2025, 4(2), 219–232.
Ling Hu#, Miao Li#, Yueqian Sang#, Chengxin Zhao#, Jiwu Huang, Wei Huang, Yanqing Xue, Lei Liu, Yucheng Gu, Pengchen Ma*, Xiao-Song Xue*, Lifeng Pan*, Wen Liu*. Pseudokinase can catalyse peptide cyclization through thioether crosslinking. Nature Chemistry 2025, doi: 10.1038/s41557-025-01954-1.
Yijiao Xiong, Heng Guo, Wen Liu*. Unveiling the biosynthetic logic of nosiheptide based on reconstitution of its bicyclic thiopeptide scaffold. Journal of the American Chemical Society 2025, 147(18), 15847-15858.
Hongbo Wang#, Yike Zou#, Miao Li#, Zhijun Tang#, Jiabao Wang, Zhenhua Tian, Nina Strassner, Qian Yang, Qingfei Zheng, Yujiao Guo, Wen Liu*, Lifeng Pan*, K. N. Houk*. A cyclase that catalyses competing 2 + 2 and 4 + 2 cycloadditions. Nature Chemistry 2023, 15(2), 177-184.
Bo Pang#, Rijing Liao#, Zhijun Tang#, Shengjie Guo, Zhuhua Wu, Wen Liu*. Caerulomycin and collismycin antibiotics share a trans-acting flavoprotein-dependent assembly line for 2,2'-bipyridine formation. Nature Communications 2021, 12(1), 3124.
Qingfei Zheng#, Shoufeng Wang#, Panpan Duan, Rijing Liao, Dandan Chen, Wen Liu*. An α/β-hydrolase fold protein in the biosynthesis of thiostrepton exhibits a dual activity for endopeptidyl hydrolysis and epoxide ring opening/macrocyclization. Proceedings of the National Academy of Sciences of the United States of America 2016, 113(50), 14318-14323.
Qunfei Zhao#, Min Wang#, Dongxiao Xu, Qinglin Zhang, Wen Liu*. Metabolic coupling of two small-molecule thiols programs the biosynthesis of lincomycin A. Nature 2015, 518(7537), 115-119.
Zhenhua Tian#, Peng Sun#, Yan Yan#, Zhuhua Wu, Qingfei Zheng, Shuaixiang Zhou, Hua Zhang, Futao Yu, Xinying Jia, Dandan Chen, Attila Mándi, Tibor Kurtán, Wen Liu*. An enzymatic [4+2] cyclization cascade creates the pentacyclic core of pyrroindomycins. Nature Chemical Biology 2015, 11(4), 259-265.