TANG ZHIJUN

  • Tel: +86-021
  • Email: tangzhijun1990@sjtu.edu.cn
  • Address: School of Life Science & Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, China
  • Tenure-track Associate Professor and Ph.D. supervisor. His research focuses on natural product biosynthesis and biocatalysis. Recipient of the Excellent Young Scholars Fund of NSFC and the Shanghai Rising-Star Program. Postdocs with backgrounds in biocatalysis, biochemistry, organic or natural product chemistry are welcome.

Selected Publications

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    Song, H.; Zhang, Z.; Cao, C.*; Tang, Z.*, Gui, J.* & Liu, W.*, Biocatalytic Steroidal 9α-Hydroxylation and Fragmentation Enable a Concise Chemoenzymatic Synthesis of 9,10-Secosteroids. Angew. Chem. Int. Ed. Engl. 2024, 63, e202319624. (Corresponding author)

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    Tang, Z. #; Pang, B.#; Liu, C.#(Co-first); Guo, S.; Qu, X. & Liu, W.*, Formation and Loading of a (2S)-2-ethyl-malonamyl-ACP Starter Unit in the Assembly Line of Polyketide-Nonribosomal Peptide Hybrid Sanglifehrin A. Angew. Chem. Int. Ed. Engl. 2023, 62, e202217090.

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    Guo, S.; Sang, Y.; Zheng, C.; Xue, X.; Tang, Z.* & Liu, W.*, Enzymatic α-Ketothioester Decarbonylation Occurs in the Assembly Line of Barbamide for Skeleton Editing. J. Am. Chem. Soc. 2023, 45, 9, 5017–5028.(Corresponding author)

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    Wang, H. #; Zou, Y. #; Li, M. #; Tang, Z. #; Wang, J.; Tian, Z.; Strassner, N.; Yang, Q.; Zheng, Q.; Guo, Y.; Liu, W. *; Pan, L.* & Houk, K. N.*, A Cyclase that Catalyses Competing 2+2 and 4+2 Cycloadditions. Nat. Chem. 2023, 15, 177–184.(Co-first author) 

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    Tang, Z. #; Tang, H. #; Wang, W. #(Co-first); Xue, Y.; Chen, D.; Tang, W. & Liu, W., Biosynthesis of a New Fusaoctaxin Virulence Factor in Fusarium graminearum Relies on a Distinct Path to Form a Guanidinoacetyl Starter Unit Priming Nonribosomal Octapeptidyl Assembly. J. Am. Chem. Soc. 2021. 143, 19719−19730.

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    Pang, B. #; Liao, R. #; Tang, Z. #; Guo, S.; Wu, Z. & Liu, W., Caerulomycin and collismycin antibiotics share a trans-acting flavoprotein-dependent assembly line for 2,2'-bipyridine formation. Nat. Commun. 2021, 12 (1), 3124. (Co-first author)

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    Zhang, D.#; Tang, Z.#  & Liu, W., Biosynthesis of Lincosamide Antibiotics: Reactions Associated with Degradation and Detoxification Pathways Play a Constructive Role, Acc. Chem. Res. 2018, 51, 1496. (Co-first author)

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    Tang, Z., Wang, H, & Liu, W., Enzyme-Associated Pericyclic Reactions, 2020, Book Chapter in “Comprehensive Natural Products III”

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    Zhao, Y.#; Zhang, W.#; Cao, C.*; Liu, W.* & Tang, Z.*, Noncanonical Functions of Ketosynthase Domains in Type I Polyketide Synthases. Chembiochem 2024, 63, e202400751.

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    Ding, W.#; Zhou, M.#; Li, H.; Li, M.; Qiu, Y.; Yin, Y.; Pan, L.; Du, Y.*; Zhang, X.*; Tang, Z.* & Liu, W*, Biocatalytic Fluoroalkylation Using Fluorinated S-adenosyl-L-methionine Cofactors. Org. Lett, 2023, 25, 5650-5655.(Corresponding authors) 

Academic Rewards

  • NSFC Excellent Young Scientists Fund (2025)
  • Shanghai Rising Star in Science and Technology (2024)