Tenure-track associate professor. Our lab studies the molecular mechanism of eukaryotic DNA replication, the roles of DNA replication and repair proteins in genome stability maintenance and cancer suppression.
Education and Research Experience
2020.12-Present, Tenure-track associate professor, PI, Shanghai Jiao Tong Univeristy, China.
2016-2020 Postdoc, Memorial Sloan-Kettering Cancer Center, USA.
2009-2015 PhD, Biochemistry, Texas A&M University, USA.
Meng X, Claussin C, Regan-Mochrie G, Whitehouse I, Zhao X. (2023) Balancing act of a leading strand DNA polymerase-specific domain and its exonuclease domain promotes genome-wide sister replication fork symmetry. Genes & Development. doi:10.1101/gad.350054.122
Meng X#, Wei L#, Peng XP, and Zhao X*. (2019) Sumoylation of DNA polymerase ε by the Smc5/6 complex contributes to DNA Replication. PLoS Genet. 15(11):e1008426.
Dhingra N, Kuppa S, Wei L, Pokhrel N, Baburyan S, Meng X, Antony E, Zhao X. (2021) The Srs2 helicase dampens DNA damage checkpoint by recycling RPA from chromatin. Proc Natl Acad Sci U S A.118(8):e2020185118.
Wan B, Wu J, Meng X, Lei M, Zhao X*. (2019) Molecular basis for control of diverse genome stability factors by the multi-BRCT scaffold Rtt107. Mol Cell. 75(2):238-251.
Sandoval PY#, Lee PH#, Meng X#, Kapler GM*. (2015) Checkpoint activation of an unconventional DNA replication program in Tetrahymena. PLoS Genet. 11(7):e1005405.