Meng Xiangzhou

Tenure-track Associate Professor

  • Tel: +86-021
  • Email: mengx@sjtu.edu.cn
  • Tenure-track associate professor. Our lab studies the molecular mechanism of eukaryotic DNA replication, the roles of DNA replication and repair proteins in genome stability maintenance and cancer suppression.

Education and Research Experience

  • 2020.12-Present, Tenure-track associate professor, PI, Shanghai Jiao Tong Univeristy, China.
  • 2016-2020 Postdoc, Memorial Sloan-Kettering Cancer Center, USA.
  • 2009-2015 PhD, Biochemistry, Texas A&M University, USA.
  • 2006 -2009 Master, Microbiology, Shandong Univeristy, China.
  • 2002-2006 Bachelor, Biotechnology, Shandong University, China.

Selected Publications

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    Meng X, Claussin C, Regan-Mochrie G, Whitehouse I, Zhao X. (2023) Balancing act of a leading strand DNA polymerase-specific domain and its exonuclease domain promotes genome-wide sister replication fork symmetry. Genes & Development. doi:10.1101/gad.350054.122

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    Meng X, Dang HQ, Kapler GM. (2023) Developmentally Programmed Switches in DNA Replication: Gene Amplification and Genome-Wide Endoreplication in Tetrahymena. Microorganisms. 11 (2), 491.

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    Meng X, Wei L, Devbhandari S, Zhang T, Xiang J, Remus D, Zhao X*. (2020) DNA polymerase ε relies on a unique domain for efficient replisome assembly and strand synthesis. Nat Commun. 11(1):2437.

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    Meng X#, Wei L#, Peng XP, and Zhao X*. (2019) Sumoylation of DNA polymerase ε by the Smc5/6 complex contributes to DNA Replication. PLoS Genet. 15(11):e1008426.

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    Meng X, Zhao X*. (2017) Replication fork regression and its regulation. FEMS Yeast Res. 17(1):fow110.

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    Dhingra N, Kuppa S, Wei L, Pokhrel N, Baburyan S, Meng X, Antony E, Zhao X. (2021) The Srs2 helicase dampens DNA damage checkpoint by recycling RPA from chromatin. Proc Natl Acad Sci U S A.118(8):e2020185118.

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    Wan B, Wu J, Meng X, Lei M, Zhao X*. (2019) Molecular basis for control of diverse genome stability factors by the multi-BRCT scaffold Rtt107. Mol Cell. 75(2):238-251.

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    Lee PH#, Meng X#, Kapler GM*. (2015) Developmental regulation of the Tetrahymena thermophila origin recognition complex. PLoS Genet. 11(1):e1004875.

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    Sandoval PY#, Lee PH#, Meng X#, Kapler GM*. (2015) Checkpoint activation of an unconventional DNA replication program in Tetrahymena. PLoS Genet. 11(7):e1005405.