Xiaofei Li

  • Tel: +86-02134205134
  • Email: xiaofeili@sjtu.edu.cn
  • Address: https://scholar.google.com/citations?user=bcL5O5YAAAAJ&hl=en
  • Group leader, tenue-track associate professor. Our team focuses on studying the pathogenesis and resolution of chronic inflammatory diseases and comorbidities; investigating the epigenetic mechanisms of innate immune memory in hematopoietic stem cells, using cellular, molecular biology and single-cell omics technologies.

Selected Publications

  • •  

    Xiaofei Li*, Hui Wang*, Xiang Yu, Gundappa Saha, Lydia Kalafati, Charalampos Ioannidis, Ioannis Mitroulis, Mihai G Netea, Triantafyllos Chavakis, George Hajishengallis. Maladaptive innate immune training of myelopoiesis links inflammatory comorbidities. Cell, 2022 May 12;185(10):1709-1727.e18.

    •  

    Ioannis Kourtzelis*, Xiaofei Li*, Ioannis Mitroulis, Daniel Grosser, Tetsuhiro Kajikawa, Baomei Wang, Michal Grzybek, Janusz Von Renesse, Aleksander Czogalla, Maria Troullinaki, Anaisa Ferreira, Christian Doreth, Klara Ruppova, Lan-Sun Chen, Kavita Hosur, Jong-Hyung Lim, Kyoung-Jin Chung, Sylvia Grossklaus, Anne Kathrin Tausche, Leo AB Joosten, Niki M Moutsopoulos, Ben Wielockx, Antonio Castrillo, Jonathan M Korostoff, Ünal Coskun, George Hajishengallis, Triantafyllos Chavakis. DEL-1 promotes macrophage efferocytosis and clearance of inflammation. Nat. Immunol. 2019 Jan;20(1):40-49.

    •  

    Xiaofei Li*, Alessandra Colamatteo*, Lydia Kalafati, Tetsuhiro Kajikawa, Hui Wang, Jong-Hyung Lim, Khalil Bdeir, Kyoung-Jin Chung, Xiang Yu, Clorinda Fusco, Antonio Porcellini, Salvatore De Simone, Giuseppe Matarese, Triantafyllos Chavakis, Veronica De Rosa, George HajishengallisThe DEL-1/β3 integrin axis promotes regulatory T cell responses during inflammation resolution. J Clin Invest. 2020 Dec 1; 130(12): 6261–6277.

    •  

    George Hajishengallis#, Xiaofei Li#, Triantafyllos Chavakis#. Immunometabolic control of hematopoiesis. Mol. Asp. Med. 2021 Feb;77:100923. 

    •  

    Lydia Kalafati, Ioannis Kourtzelis, Jonas Schulte-Schrepping, Xiaofei Li, Aikaterini Hatzioannou, Tatyana Grinenko, Eman Hagag, Anupam Sinha, Canan Has, Sevina Dietz, Antonio Miguel de Jesus Domingues, Marina Nati, Sundary Sormendi, Ales Neuwirth, Antonios Chatzigeorgiou, Athanasios Ziogas, Mathias Lesche, Andreas Dahl, Ian Henry, Pallavi Subramanian, Ben Wielockx, Peter Murray, Peter Mirtschink, Kyoung-Jin Chung, Joachim L Schultze, Mihai G Netea, George Hajishengallis, Panayotis Verginis, Ioannis Mitroulis, Triantafyllos Chavakis. Innate immune training of granulopoiesis promotes anti-tumor activity. Cell. 2020 Oct 29;183(3):771-785.e12.

  • •  

    Hui Wang, Xiaofei Li, Tetsuhiro Kajikawa, Jieun Shin, Jong-Hyung Lim, Ioannis Kourtzelis, Kosuke Nagai, Jonathan M Korostoff, Sylvia Grossklaus, Ronald Naumann, Triantafyllos Chavakis, George Hajishengallis. Stromal cell–derived DEL-1 inhibits Tfh cell activation and inflammatory arthritis. J. Clin. Investig. 2021 Oct 1;131(19):e150578.

    •  

    Da-Yo Yuh, Tomoki Maekawa, Xiaofei Li, Tetsuhiro Kajikawa, Khalil Bdeir, Triantafyllos Chavakis, George Hajishengallis. The secreted protein DEL-1 activates a β3 integrin–FAK–ERK1/2–RUNX2 pathway and promotes osteogenic differentiation and bone regeneration. J. Biol. Chem. 2020 May 22;295(21):7261-7273.