Zhi Lin

  • Tel: +86-021
  • Email: Linz@sjtu.edu.cn
  • Address: 2-508, 1308 Keyuan Road, Shanghai

Selected Publications

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    Lin, Z.#; Ji, J.; Zhou, S. X.; Zhang, F.; Wu, J. Q.; Guo, Y. L.; Liu, W.* Processing 2-Methyl-l-Tryptophan through Tandem Transamination and Selective Oxygenation Initiates Indole Ring Expansion in the Biosynthesis of Thiostrepton. J. Am. Chem. Soc. 2017,139, 12105-12108. 

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    Lin, Z.#; He, Q. L.#; Liu, W.* Bio-inspired Engineering of Thiopeptide Antibiotics advances the Expansion of Molecular Diversity and Utility. Curr. Opin. in Biotechnol. 2017, 48, 210-219.

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    Wang, J.#; Lin, Z.#; Bai, X. B.; Tao, J.*; Liu, W.* Optimal Design of Thiostrepton-derived Thiopeptide Antibiotics and Their Potential Application against Oral Pathogens. Org. Chem. Front. 2019, 6, 1194-1199.

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    Liu, J. Y.#; Lin, Z.#; Li, Y. Q.; Zheng, Q. F.; Chen. D. D.; Liu, W.* Insights into the Thioamidation of Thiopeptins to Enhance the Understanding of the Biosynthetic Logic of Thioamide-Containing Thiopeptides. Org. Biomol. Chem. 2019, 17, 3732-3736.

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    Liu, J. Y.#; Lin, Z.#; Chen, H.; Guo, H.; Tao, J.; Liu, W.* Biosynthesis of the Central Piperidine Nitrogen Heterocycle in Series a Thiopeptides. Chin. J. Chem. 2019, 37, 35-41.

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    Biosynthesis-based artificial evolution of microbial natural products

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    Molecular basis of regio- and stereo-specificity in biosynthesis of bacterial heterodimeric diketopiperazines

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    Zhi Lin#, Yufeng Xue#, Xiao-wei Liang , Jian Wang , Shuangjun Lin , Jiang Tao, Shu-Li You*, Wen Liu*. Oxidative Indole Dearomatization for Asymmetric Furoindoline Synthesis by a Flavin-Dependent Monooxygenase Involved in the Biosynthesis of Bicyclic Thiopeptide Thiostrepton. Angew Chem Int Ed Engl. 2021,60(15):8401-8405.

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    Chenghai Sun, Wenya Tian, Zhi Lin*, Xudong Qu*. Biosynthesis of pyrroloindoline-containing natural products. Natural Product Reports 2022, 39, 1721-1765.

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    Lin Z#*, Hu Z#, Zhou L, Liu B, Huang X, Deng Z, Qu X*. A large conserved family of small-molecule carboxyl methyltransferases identified from microorganisms. Proc Natl Acad Sci U S A. 2023, doi: 10.1073/pnas.2301389120.