Cao Qin

  • Tel: +86-021
  • Email: caoqin@sjtu.edu.cn(招聘结构生物学、分子生物学方向博士后)
  • Address: 800 Dongchuan Rd., Minghang District, Shanghai, China, 200240
  • PI, Bio-X institutes at SJTU. My study focus on the cryo-EM structure determination of amyloid fibrils, and design inhibitors based on the structures. First-author papers are published in Nature (2022)、Nat. Chem. (2018)、Nat. Struct. & Mol. Bio. (2018, 2019, 2020, 2021), etc.

Education and Research Experience

  • Sep 2019-Apr 2021:University of California, Los Angeles; Assistant project scientist
  • Sep 2013-Sep 2019:University of California, Los Angeles; Postdoc
  • Sep 2008-Jul 2013:Peking University, School of Life Sciences; Ph.D.
  • Sep 2004-Jul 2008:Shanghai JiaoTong Univeristy, School of Life Sciences and Biotechnology; B.D.

Selected Publications

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    Cheng, Y., Han, J., Song, M., Zhang S., Cao, Q#. Serine peptidase Vpr forms enzymatically active fibrils outside Bacillus bacteria revealed by cryo-EM. Nat Commun 14, 7503 (2023). 

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    Jiang, Y. X*., Cao, Q*., Sawaya, M. R., Abskharon, R., Ge, P., DeTure, M., Dickson, D. W., Fu, J. Y., Loo, R. R. O., Loo, J. A., and Eisenberg, D. S., “Amyloid fibrils in disease FTLD-TDP are composed of TMEM106B not TDP-43” Nature, 605:304–309 (2022)

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    Cao, Q., Boyer, D. R., Sawaya, M. R., Abskharon, R., Saelices, L., Nguyen, B.A., Lu J., Murry, K.A., Kandeel, F., and Eisenberg, D.S., “Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores” Nature Structural & Molecular Biology, 28:724-730 (2021)

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    Cao, Q., Boyer, D. R., Sawaya, M. R., Ge, P., and Eisenberg, D.S., “Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils.” Nature Structural & Molecular Biology, 27:653-659 (2020)

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    Cao, Q*., Boyer, D. R*., Sawaya, M. R., Ge, P., and Eisenberg, D.S., “Cryo-EM structures of four polymorphic TDP-43 amyloid cores.” Nature Structural & Molecular Biology, 26: 619-627 (2019)

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    Cao, Q., Shin, W. S., Chan, H., Vuong, C. K., Dubois, B., Li, B., Murray, K. A., Sawaya, M. R., Feigon, J., Black, D. L., Eisenberg, D. S., and Jiang, L., “Inhibiting amyloid-β cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design.” Nature Chemistry, 10: 1213–1221 (2018)

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    Guenther, E. L*., Cao, Q*., Trinh, H., Lu, J., Sawaya, M. R., Cascio, D., Boyer, D. R., Rodriguez, J. A., Hughes, M. P., and Eisenberg, D. S., “Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation.” Nature Structural & Molecular Biology, 25: 463-471 (2018)

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    Cao, Q., Anderson, D.H., Liang, W., Chou, J., and Saelices, L., “The inhibition of cellular toxicity of amyloid-beta by dissociated transthyretin.” The Journal of Biological Chemistry, 295, 14015-14024 (2020)

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    Wang, X.-J., Cao, Q., Zhang, Y., and Su, X.-D., “Activation and Regulation of Caspase-6 and Its Role in Neurodegenerative Diseases.” Annual Review of Pharmacology and Toxicology, 55: 553–572 (2015)

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    Cao, Q., Wang, X.-J., Li, L.-F., and Su, X.-D., “The regulatory mechanism of the caspase 6 pro-domain revealed by crystal structure and biochemical assays.” Acta Crystallographica Section D Biological Crystallography, 70: 58–67 (2014)