Cao Qin

  • Tel: +86-021
  • Email: caoqin@sjtu.edu.cn(招聘结构生物学、分子生物学方向博士后)
  • Address: 800 Dongchuan Rd., Minghang District, Shanghai, China, 200240
  • PI, Bio-X institutes at SJTU. My study focus on the cryo-EM structure determination of amyloid fibrils, and design inhibitors based on the structures. First-author papers are published in Nature (2022)、Nat. Chem. (2018)、Nat. Struct. & Mol. Bio. (2018, 2019, 2020, 2021), etc.

Education and Research Experience

  • Sep 2019-Apr 2021:University of California, Los Angeles; Assistant project scientist
  • Sep 2013-Sep 2019:University of California, Los Angeles; Postdoc
  • Sep 2008-Jul 2013:Peking University, School of Life Sciences; Ph.D.
  • Sep 2004-Jul 2008:Shanghai JiaoTong Univeristy, School of Life Sciences and Biotechnology; B.D.

Selected Publications

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    Cheng, Y., Kreutzberger, M., Han, J., Egelman, E#., and Cao, Q#. Molecular architecture of the assembly of Bacillus spore coat protein GerQ revealed by cryo-EM. Nat Commun 15, 8091 (2024). 

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    Cheng, Y., Han, J., Song, M., Zhang S., Cao, Q#. Serine peptidase Vpr forms enzymatically active fibrils outside Bacillus bacteria revealed by cryo-EM. Nat Commun 14, 7503 (2023). 

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    Jiang, Y. X*., Cao, Q*., Sawaya, M. R., Abskharon, R., Ge, P., DeTure, M., Dickson, D. W., Fu, J. Y., Loo, R. R. O., Loo, J. A., and Eisenberg, D. S., “Amyloid fibrils in disease FTLD-TDP are composed of TMEM106B not TDP-43” Nature, 605:304–309 (2022)

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    Cao, Q., Boyer, D. R., Sawaya, M. R., Abskharon, R., Saelices, L., Nguyen, B.A., Lu J., Murry, K.A., Kandeel, F., and Eisenberg, D.S., “Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores” Nature Structural & Molecular Biology, 28:724-730 (2021)

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    Cao, Q., Boyer, D. R., Sawaya, M. R., Ge, P., and Eisenberg, D.S., “Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils.” Nature Structural & Molecular Biology, 27:653-659 (2020)

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    Cao, Q*., Boyer, D. R*., Sawaya, M. R., Ge, P., and Eisenberg, D.S., “Cryo-EM structures of four polymorphic TDP-43 amyloid cores.” Nature Structural & Molecular Biology, 26: 619-627 (2019)

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    Han, J., Song, M., Cheng, Y., Gong, W., Zhang, F#., and Cao, Q#., “Structure of human glycoprotein 2 reveals mechanisms underlying filament formation and adaption to proteolytic environment in the digestive tract” PLOS Biology (epub ahead of print)

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    Jiang, Y., Peña-Díaz, S#., Zhang, Z., Daugberg, A. O. H., Hemnández, M. L., Nielsen, J., Huang. Q., Qin, S., Dueholm, M. K. D., Dong, M., Pederen, J. S., Cao, Q#., Otzen, D#., and Wang, H#., “Natural design of a stabilized cross-β fold: Structure of the FuA FapC from Pseudomonas sp. UK4 reveals a critical role for stacking of imperfect repeats” Advanced Materials, 37, 250503 (2025)

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    Song, M., Han, J., and Cao, Q#., “Cryo-EM structure of amyloid fibrils formed by full-length human αA-crystallin with pathogenic mutation R116C” Communications Chemistry, 8, 233 (2025)

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    Li, S., Li, S., Cheng, Y., Fang, Y#., Cao, Q#., and Cao, Y#., “Dual hydrophilic-hydrophobic core architecture in soy glycinin amyloid fibrils revealed by cryo-EM” Advanced Science (epub ahead of print)