Yafei Mao

  • Tel: +86-021-62932151
  • Email: yafmao@sjtu.edu.cn
  • Address: Little White House, 1954 Huashan Road, Shanghai, 200030, China
  • Lab Web: https://www.yafmao.org/
  • Our lab has broad interests in evolution, genomics, and neurological diseases. We combine experimental and computational approaches to investigate (epi)genomic changes in primate evolution.
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Education and Research Experience

  • EDUCATION
  • 2019  Ph.D. Okinawa Institute of Science and Technology Graduate University
  • 2014  B.Sc.  Nanjing University (with honor)
  • Other Training:  
  • May 2018 - Oct 2018      Princeton University
  • Oct 2013 - Mar 2014      Hong Kong University of Science and Technology

 

  • APPOINTMENTS
  • Shanghai Jiao Tong University
  • May 2025 - present        Professor

  • May 2022 - May 2025         Associate Professor

  • University of Washington
  • Jun 2019 - May 2022      Postdoctoral Fellow 
  • Okinawa Institute of Science and Technology Graduate University
  • May 2019 - Jun 2019       Junior Researcher

Research Interests

Evolutionary Genomics

Our lab has broad interests in ecological and evolutionary genomics. Our research focuses on two main topics: structural variation (SV) and gene tree discordance (GTD). We combine experimental and computational approaches to investigate genome architectures of SV and GTD in corals and primates. We aim to understand how those architectures are associated with the origins of human genetic diseases and the adaptive evolution of corals and primates.

Selected Publications

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    Zhang, S., Xu, N., Fu, L., Yang, X., Li, Y., Yang, Z., ... Sun, Q.* & Mao, Y.* (2025).

    Integrated analysis of the complete sequence of a macaque genome. Nature, 1-8

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    Ma, K., Yang, X., Mao, Y.* (2025). Advancing evolutionary medicine with complete primate genomes and advanced biotechnologies. Trends in Genetics, 41(3),201-217.

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    Mao, Y.*, Harvey, W. T., Porubsky, D., Munson, K. M., Hoekzema, K., Lewis, A. P., ... & Eichler, E. E.* (2024). Structurally divergent and recurrently mutated regions of primate genomes. Cell

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    Yang, X., Wang, X., Zou, Y. ... Mao, Y.*. (2023). Characterization of large-scale genomic differences in the first complete human genome. Genome Biology, 24, 157.

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    Mao, Y., Catacchio, C.R., Hillier, L.W., Porubsky, D., Li, R., Sulovari, A., ... & Eichler, E.E. (2021). A high-quality bonobo genome refines the analysis of hominid evolution. Nature

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