Ya Guo

Tenure-track Associate Professor

  • Tel: +86-021-34204127
  • Email: guoya@sjtu.edu.cn
  • Address: Rm. 4A-411, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China
  • PI, Sheng Yushou Center of Cell Biology and Immunology & Department of Genetics and Developmental Science, Shanghai Jiao Tong University. We are interested in understanding how genome is folded in three-dimensional space, and the correlation between genome organization and gene expression in mammalian cells.

Selected Publications

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    Zhu, Xinyi, et al. "3D chromosomal landscape reveals miR‐146a dysfunctional enhancer in lupus and establishes a CRISPR‐mediated approach to inhibit the IFN pathway." Arthritis & Rheumatology (2024).

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    Yin, Zihang, et al. "Identification of Two Subsets of Subcompartment A1 Associated with High Transcriptional Activity and Frequent Loop Extrusion." Biology 12.8 (2023): 1058.

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    Guo, Ya, et al. "Chromatin jets define the properties of cohesin-driven in vivo loop extrusion." Molecular Cell 82.20 (2022): 3769-3780.

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    Guo, Ya, et al. "CRISPR inversion of CTCF sites alters genome topology and enhancer/promoter function." Cell 162.4 (2015): 900-910.

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    Guo, Ya, et al. "CTCF/cohesin-mediated DNA looping is required for protocadherin α promoter choice." Proceedings of the National Academy of Sciences 109.51 (2012): 21081-21086.

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