Jinwei Zhu

  • Tel: +86-021
  • Email: jinwei.zhu@sjtu.edu.cn
  • Address:
  • Lab Web: http://www.bio-x.cn/
  • Dr. Zhu received his PhD in Chemical Biology from Fudan University. He is currently the PI of Bio-X Institutes at Shanghai Jiao Tong University, focusing on biochemical and structural basis of polarized signaling transduction in neuronal development and synaptic plasticity as well as etiology of various psychiatric disorders.

Selected Publications

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    Zhang M#, Cao A#, Lin L#, Chen Y, Shang Y, Wang C, Zhang MJ, Zhu J*. (2023) Phosphorylation-dependent recognition of diverse protein targets by the cryptic GK domain of MAGI MAGUKs. Sci Adv. 10;9(19):eadf3295.

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    Gu J#, Peng R#, Guo C#, Zhang M, Yang J, Yan X, Zhou Q, Li H, Wang N, Zhu J*, Ouyang Q*. (2022) Construction of a synthetic methodology-based library and its application in identifying a GIT/PIX protein-protein interaction inhibitor. Nat Commun. 13(1):7176.

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    Shi Y#, Lin L#, Wang C*, Zhu J*. (2022) Promotion of row 1-specific tip complex condensates by Gpsm2-Gαi provides insights into row identity of the tallest stereocilia. Sci Adv. 8(23):eabn4556.

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    Lin L#, Shi Y#, Wang M, Wang C, Lu Q, Zhu J*,1, Zhang R*. (2021) Phase separation-mediated condensation of Whirlin-Myo15-Eps8 stereocilia tip complex. Cell Rep 34(8):108770. (1Lead Contact).

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    Zhang M#, Lin L#, Wang C*, Zhu J*. (2021) Double inhibition and activation mechanisms of Ephexin family RhoGEFs. Proc Natl Acad Sci USA. 118(8) e2024465118.

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    Wang M#, Lin L#, Shi Y, He L, Wang C*, Zhu J*. (2020) Structure of the FERM domain of a neural scaffold protein FRMPD4 implicated in X-linked intellectual disability. Biochem J 477(23):4623-4634.

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    Zhu J#,*, Zhou Q#, Xia Y, Lin L, Li J, Peng M, Zhang R*, Zhang M*. (2020) GIT/PIX Condensates Are Modular and Ideal for Distinct Compartmentalized Cell Signaling. Mol Cell 79(5):782-796.e6.

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    Weng Z, Situ C, Lin L, Wu Z, Zhu J*, and Zhang R* (2019) Structure of BAI1/ELMO2 complex reveals an action mechanism of adhesion GPCRs via ELMO family scaffolds. Nat Commun 10(1):51.
     

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    Weng Z, Shang Y, Ji Z, Ye F, Lin L, Zhang R* and Zhu J* (2018) Structural basis of highly specific interaction between Nephrin and MAGI1 in slit diaphragm assembly and signaling. J Am Soc Nephrol 29(9):2362-2371.
     

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    Xia Y#, Shang Y#, Zhang R, and Zhu J* (2017) Structure of PSD95/MAP1A complex reveals unique target recognition mode of MAGUK GK domain. Biochem J 474(16):2817-2828.