于明特别研究员科研组招聘博士后或助理研究员

上海交通大学生命科学技术学院于明特别研究员的科研组招聘博士后或助理研究员如下。

 

应聘人1:在近期获得博士学位,熟悉动物细胞培养和分子生物学的基本操作。

应聘人2:在近期获得博士学位,生物信息学方向,熟悉NGS分析。

 

应聘人在入职之后可以依照学校的政策逐级晋升。工资和其它待遇面议。

 

本科研组的研究方向为血细胞发育和癌症的转录调控(Transcriptional regulation of hematopoiesis and tumorigenesis),主要利用基因组学技术(ChIP-seq、RNA-seq、Pro-seq、PA-seq和CLIP-seq)、分子遗传学技术(CRISPR-Cas9和RNAi)以及蛋白组学技术来阐明转录因子PAF1 complex、Super Elongation Complex、MLL1、GATA1 和RUNX1在生理条件下如何调控血细胞的发育,而与它们相关的转录失调如何诱发癌症。

 

联系方式:于明,邮箱: This e-mail address is being protected from spambots. You need JavaScript enabled to view it.

 

参考文献

1. Yu, M., Yang, W., Ni, T., Tang, Z., Nakadai, T., Zhu, J., and Roeder, R.G. (2015) RNA polymerase II-associated factor 1 regulates the release and phosphorylation of paused RNA polymerase II. Science 350, 1383-1386.

2. Yu, M., Mazor, T., Huang, H., Huang, H. T., Kathrein, K. L., Woo, A. J., Chouinard, C. R., Labadorf, A., Akie, T. E., Moran, T. B., Xie, H., Zacharek, S., Taniuchi, I., Roeder, R. G., Kim, C. F., Zon, L. I., Fraenkel, E., and Cantor, A. B. (2012) Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors, Mol Cell 45, 330-343.

3. Yu, M., Riva, L., Xie, H., Schindler, Y., Moran, T. B., Cheng, Y., Yu, D., Hardison, R., Weiss, M. J., Orkin, S. H., Bernstein, B. E., Fraenkel, E., and Cantor, A. B. (2009) Insights into GATA-1-Mediated Gene Activation versus Repression via Genome-wide Chromatin Occupancy Analysis, Mol Cell 36, 682-695.

4. Yu, M., Wan, M., Zhang, J., Wu, J., Khatri, R., and Chi, T. (2008) Nucleoprotein structure of the CD4 locus: implications for the mechanisms underlying CD4 regulation during T cell development, Proc Natl Acad Sci U S A 105, 3873-3878.

 

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