Ilya Vinnikov 的个人介绍页
Ilya Vinnikov
Ilya Vinnikov


2008-03-31: 医学博士(荣誉-优等) 海德堡大学 医学院 论文题目:活化蛋白C在糖尿病中对细胞进行保护的分子机制
2003-06-30:理科硕士(优等) 莫斯科州立大学 基础医学 论文题目:活化蛋白C在糖尿病中对细胞进行保护的分子机制

2014-2016:联合研究员——分子细胞生物学和分子代谢控制 德国海德堡癌症研究中心(DKFZ) 海德堡大学。
2008-2009:博士后——内科医学 海德堡大学医学院。
2004-2008:研究员(博士)——内科医学 海德堡大学医学医院。


Keywords: neuroscience, microRNA, metabolism, neurodegeneration, obesity, circadian, transcription regulation and epigenetic control in eukaryotes, mouse.

Chronic metabolic and neurodegenerative syndromes, such as diabetes mellitus, obesity or Parkinson’s disease, represent a growing epidemic, especially in the constantly aging western populations. These currently incurable complex traits result from a failure in the interplay of environmental factors, humoral signals, extra- and intracellular enzymatic cascades, genetic and epigenetic signals in the central nervous system and in the periphery. Physiological and pathophysiological mechanisms involved in these processes require intensive research to provide the patients with novel therapeutic strategies. The lab has a strong interest in studying the role of distinct neuronal population-specific non-coding RNAs in chronic complex traits disorders. In perspective, the integration of expression and functional data from mouse and patient brain samples will provide novel insights for future genome wide association studies aiming to identify genetic variants within non-coding RNA genes and/or within the genes influenced by these RNA species aiming to decipher the mechanisms involved in metabolic and neurodegenerative disorders.  


Original publications:
1. Domanskyi A., Alter H., Vogt M.A., Gass P., and Vinnikov I.A. (2014) Transcription factors Foxa1 and Foxa2 are required for adult dopamine neurons maintenance, Front Cell Neurosci 8.
2. Vinnikov I.A.§, Hajdukiewicz K., Reymann J., Beneke J., Czajkowski R., Roth L.C., Novak M., Roller A., Dörner N., Starkuviene V., Theis F.J., Erfle H., Schütz G., Grinevich V., and Konopka W. (2014) Hypothalamic miR-103 Protects from Hyperphagic Obesity in Mice, The Journal of Neuroscience 34, 10659-10674. §, co-corresponding author.
3. Wang H., Vinnikov I., Shahzad K., Bock F., Ranjan S., Wolter J., Kashif M., Oh J., Bierhaus A., Nawroth P., Kirschfink M., Conway E.M., Madhusudhan T., and Isermann B. (2012) The lectin-like domain of thrombomodulin ameliorates diabetic glomerulopathy via complement inhibition, Thromb Haemost 108, 1141-1153.
4. Wang H., Madhusudhan T., He T., Hummel B., Schmidt S., Vinnikov I.A., Shahzad K., Kashif M., Muller-Krebs S., Schwenger V., Bierhaus A., Rudofsky G., Nawroth P.P., and Isermann B. (2011) Low but sustained coagulation activation ameliorates glucose-induced podocyte apoptosis: protective effect of factor V Leiden in diabetic nephropathy, Blood 117, 5231-5242.
5. Kashif M., Hellwig A., Kolleker A., Shahzad K., Wang H., Lang S., Wolter J., Thati M., Vinnikov I., Bierhaus A., Nawroth P.P., and Isermann B. (2011) p45NF-E2 represses Gcm1 in trophoblast cells to regulate syncytium formation, placental vascularization and embryonic growth, Development 138, 2235-2247.
6. Domanskyi A., Geissler C., Vinnikov I.A., Alter H., Schober A., Vogt M.A., Gass P., Parlato R., and Schuetz G. (2011) Pten ablation in adult dopaminergic neurons is neuroprotective in Parkinson's disease models, Faseb Journal 25, 2898-2910.
7. Seehaus S., Shahzad K., Kashif M., Vinnikov I.A., Schiller M., Wang H., Madhusudhan T., Eckstein V., Bierhaus A., Bea F., Blessing E., Weiler H., Frommhold D., Nawroth P.P., and Isermann B. (2009) Hypercoagulability Inhibits Monocyte Transendothelial Migration Through Protease-Activated Receptor-1-, Phospholipase-C beta-, Phosphoinositide 3-Kinase-, and Nitric Oxide-Dependent Signaling in Monocytes and Promotes Plaque Stability, Circulation 120, 774-U141.
8. Isermann B., Vinnikov I.A.*, Madhusudhan T., Herzog S., Kashif M., Blautzik J., Corat M.A.F., Zeier M., Blessing E., Oh J., Gerlitz B., Berg D.T., Grinnell B.W., Chavakis T., Esmon C.T., Weiler H., Bierhaus A., and Nawroth P.P. (2007) Activated protein C protects against diabetic nephropathy by inhibiting endothelial and podocyte apoptosis, Nature Medicine 13, 1349-1358. *, equally contributed first author.
• previewed in: Brownlee M. (2007) Preventing kidney cell suicide, Nature Medicine 13, 1284-1285.
• highlighted in: Gilbert R.E., and Marsden P.A. (2008) Activated Protein C and Diabetic Nephropathy, New England Journal of Medicine 358, 1628-1630.
9. Zakharova M.Y., Kozyr A.V., Ignatova A.N., Vinnikov I.A., Shemiyakin I.G., and Kolesnikov A.V. (2005) Purification of filamentous bacteriophage for phage display using size-exclusion chromatography, Biotechniques 38, 194-198.

Book chapters:
1. Vinnikov I.A., Nawroth P.P., Isermann B.: Thrombomodulin-Protein-C-System, Protein Z. In: Pötzsch B., Madlener K., eds. Hämostaseologie (Haemostaseology). Berlin, Germany: Springer-Verlag, 2010: 245-258.
2. Grinevich V., Knobloch S., Roth L.C., Althammer F., Domansky A., Vinnikov I., Eliava M., Stanifer M., Boulant S.: Somatic transgenesis (Viral vectors). In: Murphy D. and Gainer H., eds. Master Classes in Molecular Neuroendocrinology: From genome to physiology. West Sussex, England: John Wiley & Sons, 2015: 243-274.

Other contributions:
1. Isermann B., Thati M., Vinnikov I., Herzog S., Huntscha S., Bender R., Weiler H., Bierhaus A., and Nawroth P.P. (2005) Loss of TM-dependent PC-activation predisposes to diabetic nephropathy: Potential role of endothelial apoptosis, Blood 106, 301A-301A.
2. Vinnikov I., Thati M., Herzog H., Huntscha S., Blautzik J., Bünder R., Chavakis T., Blessing E., Weiler H., Nawroth P.P., Bierhaus A., Isermann B. (2006). The thrombomodulin protein C system protects against diabetic nephropathy.: Professor Duckert Symposium in the 50th meeting of the Society of Thrombosis and Hemostasis Research, Basel, Switzerland. 10 best abstracts.
3. Vinnikov I., Hummel B, Thati M., Huntscha S., Herzog H., Bierhaus A., Nawroth P.P., Isermann B. (2006). The coagulation system regulates diabetic microvascular complications independent of blood clotting. The 43d Conference of the South-Western Germany Internal Medicine Society, Baden-Baden, Germany.
4. Vinnikov I., Hummel B, Thati M., Huntscha S., Herzog H., Bierhaus A., Nawroth P.P., Isermann B. (2006). Disruption of the TM-PC anticoagulant pathway at different levels has opposing effects on diabetic nephropathy: impaired PC-activation, but not factor V Leiden, aggravates diabetic nephropathy. The 49th Meeting of the German United Society of Clinical Chemistry and Laboratory Medicine (DGKL), Mannheim, Germany.
5. Vinnikov I., Madhusudhan T., Muhammed K., Herzog S.U.E., Huntscha S., Weiler H., Brueckmann M., Lang S., Nawroth P.P., Isermann B. (2007). Thrombomodulin Protein C System Prevents Inflammatory Phenotype and Altered Gene Expression Profile in Diabetic Nephropathy. The 51st meeting of the Society of Thrombosis and Hemostasis Research, Dresden, Germany.
6. Isermann B., Vinnikov I., Hummel B., Madhusudhan T., Kashif M., Herzog S., Bierhaus A., Nawroth P. P. (2007) Factor V Leiden Protects Against Diabetic Nephropathy in Mice. The 21st Congress of the International Society on Thrombosis and Haemostasis, Geneva, Switzerland.
7. Herzog S.U.E., Gasque P., Maul H., Sinn H.P., Kashif M., Kranz C., Huntscha S., Vinnikov I., Nawroth P.P., and Isermann B. (2007) Tumor endothelial marker 1 (TEM1, endosialin) is expressed in functional and morphological distinct trophoblast cells in human and mouse placenta, Thrombosis Research 119, S106-S106.
8. Vinnikov I., Madhusudhan T., Kashif M., Engel J., HerzogvS, Nawroth P.P., Isermann B. (2007) Anticoagulation abolishes activated Protein C dependent nephroprotection in diabetes mellitus: in vivo evidence for a role of activated Protein C independent of anticoagulation. United Meeting of German and Austrian Societies of Clinical Chemistry and Laboratory Medicine, Vienna, Austria. Sigi-Ziering Prize.
9. Isermann B., Vinnikov I., Hummel B., Madhusudhan T., Kashif M., Herzog S., Bierhaus A., and Nawroth P.P. (2007) The endothelial thrombomodulin protein C system modulates diabetic nephropathy: protective effect of the prothrombotic factor V Leiden mutation, Diabetologia 50, S465-S466.
10. Kashif M., Madhusudhan T., , Vinnikov I., Huntscha S., Nawroth P.P., and Isermann B. (2007) Absence of the transcription factor NF-E2 impairs placental labyrinthine layer development during late midgestation, Thrombosis Research 119, S108-S108.
11. Vinnikov I.A., Kashif M., Thati M., Jürgen Engel, Herzog S.U.E., Nawroth P.P., and Isermann B. (2008) Thrombomodulin-protein C system provides dual protection: the lectin-like domain of thrombomodulin prevents diabetic nephropathy. The 52d Meeting of the Society of Thrombosis and Haemosthasis, Wiesbaden, Germany. Best abstract award.
12. Vinnikov I.A., Kashif M., Thati M., Herzog S.U.E., Nawroth P.P., Isermann B. (2008) The endothelial thrombomodulin system protects against diabetic nephropathy through two independent mechanisms: role of the lectin-like domain; oral presentation. The 43d meeting of German Diabetes-Society, München, Germany.
13. Isermann B., Vinnikov I.A., Madhusudhan T., Kashif M., Herzog S.U.E., Conway E., and Nawroth P.P. (2008) Das TM-PC System schützt vor diabetischer Nephropathie durch zwei unabhängige Mechanismen: Die Bedeutung der Lektin-ähnlichen Domäne, Klinische Chemie Mitteilungen 39, 33-34.
14. Kashif M., Hellweg A., Thati M., Herzog S., Vinnikov I., Shahzad K., Nawroth P.P., and Isermann B. (2009) The transcription factor NFE2 regulates trophoblast differentiation, Thrombosis Research 123, S136-S136.
15. Wang H., Vinnikov I., Zhou Q., Madhusudhan T., Shahzad K., Kashif M., Wolter J., Bierhaus A., Nawroth P., Conway E.M., and Isermann B. (2010) The Lectin-Like Domain of Thrombomodulin Protects Against Diabetic Nephropathy by Inhibiting Complement Activation, Blood 116, 286-286.
16. Vinnikov I.A., Domanskyi A., Geißler C., Schütz G. (2010). Foxa2 protects adult dopaminergic neurons in vivo. The 7th FENS Forum of Neuroscience, Amsterdam, Holland.
17. Vinnikov I.A., Konopka W., Novak M., Hoffmann L., Kowarsch A., Theis F.J., Grinevich V., Schütz G. (2011) Hypothalamic miRNAs protect against obesity in mice. The 41st annual meeting of the Society for Neuroscience, Washington, USA. "Hot Topic" newsworthy research pool.
18. Vinnikov I.A., Konopka W., Hoffmann L., Grinevich V., Schütz G. (2012) Identification of the arcuate hypothalamic nucleus as a crucial region for the obesity phenotype in the Dicer1CamKIICreERT2 mice. The 8th FENS Forum of Neuroscience, Barcelona, Spain.
19. Vinnikov I.A., Hoffmann L., Kowarsch A., Novak M., Theis F.J., Grinevich V., Schütz G., Konopka W. (2012) Neuronal microRNAs in the arcuate hypothalamic nucleus prevent over-activation of mTOR and protect against hyperphagic obesity. EMBO Symposium DIABETES AND OBESITY, Heidelberg, Germany
20. Vinnikov I.A., Hoffmann L., Novak M., Roller A., Dörner N., Theis F.J., Grinevich V., Konopka W., Schütz G. (2013) Neuronal microRNAs from the mouse arcuate hypothalamic nucleus protect from obesity. Cold Spring Harbor Laboratory meeting on Metabolic Signalinc & Diesease: From Cell to Organism, New York, USA.


2011 Neuroscience 2011's pool of "Hot Topic" newsworthy research. Society for Neuroscience, Washington, USA.
2008 Summa cum laude M.D. degree. Faculty of Medicine, University of Heidelberg, Heidelberg, Germany.
2008 Best abstract award. Society of Thrombosis and Haemosthasis, Wiesbaden, Germany.
2007 Sigi-Ziering prize. German and Austrian Societies of Clinical Chemistry and Laboratory Medicine, Vienna, Austria.