于明 的个人介绍页
于明
于明
特别研究员
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个人简历

1996 – 2000 学士,微生物学,内蒙古大学生命科学学院
2000 – 2005 博士,生物化学与分子生物学,北京大学生命科学学院
2005 – 2007 博士后,Department of Immunobiology, Yale University School of Medicine
2007 – 2010 博士后,Boston Children’s Hospital,Harvard Medical School
2010 – 2015 博士后,Laboratory of Biochemistry & Molecular Biology,The Rockefeller University
2016 – 特别研究员,上海交通大学生命科学技术学院

研究方向

血细胞发育和癌症的转录调控。主要利用基因组学技术(ChIP-seq、RNA-seq、Pro-seq、PA-seq和CLIP-seq)、CRISPR-Cas9技术、RNAi技术和蛋白质组学技术来阐明转录调控因子PAF1 complex(Yu et al., Science, 2015)、Super Elongation Complex、MLL1、GATA1(Yu et al., Molecular Cell, 2009)和RUNX1(Yu et al., Molecular Cell, 2012; Yu et al., PNAS, 2008)在生理条件下如何调控血细胞的发育,而与它们相关的转录失调如何诱发癌症。

发表论文

1.Yu, M., Yang, W., Ni, T., Tang, Z., Nakadai, T., Zhu, J., and Roeder, R.G. (2015) RNA polymerase II-associated factor 1 regulates the release and phosphorylation of paused RNA polymerase II. Science 350, 1383-1386.
2.Gao, R., Chen, S., Kobayashi, M., Yu, H., Zhang, Y., Wan, Y., Young, S.K., Soltis, A., Yu, M., Vemula, S., et al. (2015). Bmi1 promotes erythroid development through regulating ribosome biogenesis. Stem cells 33, 925-938.
3. Shi, J., Whyte, W. A., Zepeda-Mendoza, C. J., Milazzo, J. P., Shen, C., Roe, J. S., Minder, J. L., Mercan, F., Wang, E., Eckersley-Maslin, M. A., Campbell, A. E., Kawaoka, S., Shareef, S., Zhu, Z., Kendall, J., Muhar, M., Haslinger, C., Yu, M., Roeder, R. G., Wigler, M. H., Blobel, G. A., Zuber, J., Spector, D. L., Young, R. A., and Vakoc, C. R. (2013) Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation, Genes Dev 27, 2648-2662.
4.Wang, E., Kawaoka, S., Yu, M., Shi, J., Ni, T., Yang, W., Zhu, J., Roeder, R. G., and Vakoc, C. R. (2013) Histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged leukemia, Proc Natl Acad Sci U S A 110, 3901-3906.
5.Wan, M., Gu, H., Wang, J., Huang, H., Zhao, J., Kaundal, R. K., Yu, M., Kushwaha, R., Chaiyachati, B. H., Deerhake, E., and Chi, T. (2013) Inducible mouse models illuminate parameters influencing epigenetic inheritance, Development 140, 843-852.
6.Yu, M., Mazor, T., Huang, H., Huang, H. T., Kathrein, K. L., Woo, A. J., Chouinard, C. R., Labadorf, A., Akie, T. E., Moran, T. B., Xie, H., Zacharek, S., Taniuchi, I., Roeder, R. G., Kim, C. F., Zon, L. I., Fraenkel, E., and Cantor, A. B. (2012) Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors, Mol Cell 45, 330-343.
7.Amigo, J. D., Yu, M., Troadec, M. B., Gwynn, B., Cooney, J. D., Lambert, A. J., Chi, N. C., Weiss, M. J., Peters, L. L., Kaplan, J., Cantor, A. B., and Paw, B. H. (2011) Identification of Distal cis-Regulatory Elements at Mouse Mitoferrin Loci Using Zebrafish Transgenesis, Mol Cell Biol 31, 1344-1356.
8.Yu, M., Riva, L., Xie, H., Schindler, Y., Moran, T. B., Cheng, Y., Yu, D., Hardison, R., Weiss, M. J., Orkin, S. H., Bernstein, B. E., Fraenkel, E., and Cantor, A. B. (2009) Insights into GATA-1-Mediated Gene Activation versus Repression via Genome-wide Chromatin Occupancy Analysis, Mol Cell 36, 682-695.
9.Amigo, J. D., Ackermann, G. E., Cope, J. J., Yu, M., Cooney, J. D., Ma, D., Langer, N. B., Shafizadeh, E., Shaw, G. C., Horsely, W., Trede, N. S., Davidson, A. J., Barut, B. A., Zhou, Y., Wojiski, S. A., Traver, D., Moran, T. B., Kourkoulis, G., Hsu, K., Kanki, J. P., Shah, D. I., Lin, H. F., Handin, R. I., Cantor, A. B., and Paw, B. H. (2009) The role and regulation of friend of GATA-1 (FOG-1) during blood development in the zebrafish, Blood 114, 4654-4663.
10.Huang, H., Yu, M., Akie, T. E., Moran, T. B., Woo, A. J., Tu, N., Waldon, Z., Lin, Y. Y., Steen, H., and Cantor, A. B. (2009) Differentiation-dependent interactions between RUNX-1 and FLI-1 during megakaryocyte development, Mol Cell Biol 29, 4103-4115.
11.Yu, M., Wan, M., Zhang, J., Wu, J., Khatri, R., and Chi, T. (2008) Nucleoprotein structure of the CD4 locus: implications for the mechanisms underlying CD4 regulation during T cell development, Proc Natl Acad Sci U S A 105, 3873-3878.
12.Yu, M., Yu, M., and Ru, B. (2004) Expression of an antibody-targeted plasminogen activator in Escherichia coli using chemically induced stress responses, Biotechnol Lett 26, 1629-1634.
13.Yu, M., Yu, M., and Ru, B. (2004) Enhanced expression of an antibody-targeted plasminogen activator in Escherichia coli by fusion to decorsin, Biotechnol Lett 26, 717-721.

Book chapters and invited reviews

1.Yu M, Cantor AB. Megakaryopoiesis and thrombopoiesis: an update on cytokines and lineage surface markers. Methods Mol Biol. 2012;788:291-303.

研究成果

见发表论文。