郑舰艇 的个人介绍页
郑舰艇
郑舰艇
特别研究员
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34205106

个人简历

山东大学微生物专业学士,中国科学院微生物研究所生物化学与分子生物学博士,美国马里兰大学帕克分校和德州大学奥斯汀分校博士后,中国科学院过程工程研究所生化工程国家重点实验室研究员。现任上海交通大学特别研究员,博士生导师,入选中组部第五批青年千人。主要从事结构酶学研究,以X-射线蛋白晶体衍射为主要手段解析微生物天然产物合成酶的三维结构,结合有机化学、生物化学以及分子生物学等手段阐明其分子机制,并以此为基础对天然产物合成途径进行人工优化设计和改造。相关研究已发表于Nature Chemical Biology、ACS Chemical Biology和Structure等国际期刊。

研究方向

1)天然产物合成酶的结构与功能
2)生物合成途径的基因工程改造与优化
3)微生物来源新功能酶的发现、表征与改造

发表论文

1.Wang, F., Wang, Y., Ji, J., Zhou, Z., Yu, J., Zhu, H., Su, Z., Zhang, L. & Zheng, J. (2015). Structural and functional analysis of the loading acyltransferase from avermectin modular polyketide synthase. ACS Chem Biol 10, 1017-25.
2.Piasecki, S. K., Zheng, J., Axelrod, A. J., Detelich, M. & Keatinge-Clay, A. T. (2014). Structural and functional studies of a trans-acyltransferase polyketide assembly line enzyme that catalyzes stereoselective alpha- and beta-ketoreduction. Proteins 82, 2067-77.
3.Zheng, J., Piasecki, S. K. & Keatinge-Clay, A. T. (2013). Structural studies of an A2-type modular polyketide synthase ketoreductase reveal features controlling alpha-substituent stereochemistry. ACS Chem Biol 8, 1964-71.
4.Zheng, J. & Keatinge-Clay, A. (2013). The status of type I polyketide synthase ketoreductases. Med. Chem. Commun. 4, 34-40.
5.Zheng, J., Fage, C. D., Demeler, B., Hoffman, D. W. & Keatinge-Clay, A. T. (2013). The Missing Linker: A Dimerization Motif Located within Polyketide Synthase Modules. ACS Chem Biol 8, 1263-70.
6.Zheng, J., Gay, D. C., Demeler, B., White, M. A. & Keatinge-Clay, A. T. (2012). Divergence of multimodular polyketide synthases revealed by a didomain structure. Nat Chem Biol 8, 615-21.
7.Zheng, J. & Keatinge-Clay, A. T. (2011). Structural and functional analysis of c2-type ketoreductases from modular polyketide synthases. J Mol Biol 410, 105-17.
8.Zheng, J., Taylor, C. A., Piasecki, S. K. & Keatinge-Clay, A. T. (2010). Structural and Functional Analysis of A-Type Ketoreductases from the Amphotericin Modular Polyketide Synthase. Structure 18, 913-22.
9.Zheng, J., Sagar, V., Smolinsky, A., Bourke, C., LaRonde-LeBlanc, N. & Cropp, T. A. (2009). Structure and function of the macrolide biosensor protein, MphR(A), with and without erythromycin. J Mol Biol 387, 1250-60.

研究成果

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