陈赛娟 的个人介绍页
陈赛娟
陈赛娟
教授
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64370045

个人简历

通讯地址:上海市瑞金二路197号瑞金医院上海血液学研究所
邮政编码:200025

研究方向

白血病新型诊断和治疗途径的探索;造血干细胞发育和表观遗传学

发表论文

代表性论著
1. Gu BW, Xiong H, Zhou Y, Chen B, Wang L, Dong S, Yu ZY, Lu LF, Zhong M, Yin HF, Zhu GF, Huang WH, Ren SX, R E. Gallagher, S Waxman, Chen GQ, Wang ZG, Chen Z, Fu G, Chen SJ. Variant-type PML-RAR fusion transcript in acute promyelocytic leukemia: Use of a cryptic coding sequence from intron 2 of the RAR gene and identification of a new clinical subtype resistant to retinoic acid therapy. Proc Natl Acad Sci USA 2002;99:7640–7645
2. Shen ZX, Shi ZZ, Fang J, Gu BW, Li JM, Zhu YM, Shi JY, Zheng PZ, Yan H, Chen Y, Shen Y, Wu W, Tang W, Waxman S, de Thé H, Wang ZY, Chen SJ, Chen Z. All-trans retinoic acid /As2O3 combination yields a high quality remission and survival in newly diagnosed acute promyelocytic leukemia. Proc Natl Acad Sci USA 2004;101: 5328-5335.
3. Liu H, Chen B, Xiong H, Huang QH, Zhang QH, Wang ZG, Li BL, Chen Z, Chen SJ. Functional contribution of EEN to leukemogenic transformation by MLL-EEN fusion protein. Oncogene 2004;23:3385-3394.
4. Wang YY, Zhou GB, Yin T, Chen B, Shi JY, Liang WX, Jin XL, You JH, Yang G, Shen ZX, Chen J, Xiong SM, Chen GQ, Xu F, Liu YW, Chen Z, Chen SJ. AML1-ETO and C-KIT mutation/overexpression in t(8;21) leukemia: implication in stepwise leukemogenesis and response to Gleevec. Proc Natl Acad Sci USA 2005; 102:1104-1109.
5. Chen B, Zhao WL, Jin J, Xue YQ, Cheng X, Chen XT, Cui J, Chen ZM, Cao Q, Yang G, Yao Y, Xia HL, Tong JH, Li JM, Chen J, Xiong SM, Shen ZX, Waxman S, Chen Z, Chen SJ. Clinical and cytogenetic features of 508 Chinese patients with myelodysplastic syndrome and comparison with those in Western countries. Leukemia 2005; 19:767-775.
6. Bai XT, Gu BW, Yin T, Niu C, Xi XD, Zhang J, Chen Z, Chen SJ. Trans-repressive effect of NUP98-PMX1 on PMX1-regulated c-FOS gene through recruitment of histone deacetylase 1 by FG repeats. Cancer Research 2006; 66:4584-4590.
7. Zhu YM, Zhao WL, Fu JF, Shi JY, Pan Q, Hu J, Gao XD, Chen B, Li JM, Xiong SM, Gu LJ, Tang JY, Liang H, Jiang H, Xue YQ, Shen ZX, Chen Z, Chen SJ. NOTCH1 mutations in T-cell acute lymphoblastic leukemia: prognostic significance and implication in multifactorial leukemogenesis. Clin Cancer Res. 2006;12:3043-3049.
8. Wang L, Zhao WL, Yan JS, Liu P, Sun HP, Zhou GB, Weng ZY, Wu WL, Weng XQ, Sun XJ, Chen Z, Sun HD, Chen SJ. Eriocalyxin B induces apoptosis of t(8;21) leukemia cells through NF-kappaB and MAPK signaling pathways and triggers degradation of AML1-ETO oncoprotein in a caspase-3-dependent manner. Cell Death and Differentiation 2007; 14:306-317.
9. Ma LH, Liu H, Xiong H, Chen B, Zhang XW, Wang YY, Le HY, Huang QH, Zhang QH, Li BL, Chen Z, Chen SJ. Aberrant Transcriptional Regulation of the MLL Fusion Partner EEN Gene by AML1-ETO and Its Implication in Leukemogenesis. Blood 2007; 109:769-777.
10. Zhang SJ, Ma LY, Huang QH, Li G, Gu BW, Gao XD, Shi JX, Wang YY, Gao L, Cai X, Ren RB, Zhu J, Chen Z, Chen SJ. Gain-of-function mutation of GATA-2 in acute myeloid transformation of chronic myeloid leukemia. Proc Natl Acad Sci USA 2008;105:2076-2081
11. Wang L, Zhou GB, Liu P, Song JH, Liang Y, Yang XJ, Xu F, Wang BS, Mao JH, Shen ZY, Chen SJ, Chen Z. Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia. Proc Natl Acad Sci USA 2008; 105: 4826-4831.
12. Hu J, Liu YF, Wu CF, Xu F, Shi ZX, Zhu YM, Li JM, Tang W, Zhao WL, Wu W, Sun HP, Chen QS, Chen B, Zhou GB, Zelent A, Waxman S, Wang ZY, Chen SJ, Chen Z. Long-term efficacy and safety of all-trans retinoic acid/arsenic trioxide based therapy in newly diagnosed acute promyelocytic leukemia. Proc Natl Acad Sci USA 2009;106: 3342-3347.
13. Zhang XW, Yan XJ, Yang FF, Zhou ZR, Wu ZY, Sun HB, Liang WX, Song AX, Huang QH, Zhou GB, Tong JH, Zhang Y, Wu JH, Hu HY, Chen SJ, Chen Z. Arsenic trioxide controls the fate of the PML-RAR oncoprotein by directly binding PML. Science 2010; 329: 240-243.

研究成果

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