杨选明 的个人介绍页
杨选明
杨选明
特别研究员
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个人简历

1998.9-2002.7:北京大学生命科学学院 理学学士
2002.9-2009.5:中国科学院生物物理研究所感染与免疫研究中心 博士
2009.6-2014.6:美国芝加哥大学病理学系 博士后
2014.6-2014.10: 美国芝加哥大学 助理研究员
2014.11至今:上海交通大学生命科学技术学院 特别研究员

研究方向

免疫治疗在抗感染与肿瘤治疗中有着重要的作用和非常广泛的临床应用前景。尤其是肿瘤免疫治疗,在近期获得了飞速的发展,被Science杂志评为2013年十大突破科技进展中的第一位。本实验室从基础肿瘤免疫学入手,着手于发现新的抗肿瘤机理和靶点,发展新的肿瘤免疫疗法,具体方向如下:
1.研究肿瘤微环境中的各种细胞组分对肿瘤免疫的抑制机理,发现新的肿瘤治疗靶点;
2.发展基于抗体的靶向肿瘤免疫治疗手段;
3.发展基于T细胞修饰的细胞过继性肿瘤治疗手段;
4.发展基于重组蛋白以及免疫活化的肿瘤疫苗和病原微生物疫苗;

发表论文

1.Xuanming Yang, Xunmin Zhang, Yonglian Sun, Tony Tu, Mendy Miller, Yang-Xin Fu. A BTLA-Mediated Bait and Switch Strategy Permits Listeria Expansion in CD8α(+) DCs to Promote Long-Term T Cell Responses. Cell Host & Microbe. 2014 Jul 9;16(1):68-80
2.Xiaohuan Guo, Ju Qiu, Tony Tu, Xuanming Yang, Liufu Deng, Robert A. Anders, Liang Zhou, Yang-Xin Fu. Induction of Innate Lymphoid Cell-Derived Interleukin-22 by the Transcription Factor STAT3 Mediates Protection against Intestinal Infection. Immunity. 2014 Jan 7. pii: S1074-7613(13)00555-4.
3.Xuanming Yang, Xunmin Zhang, May Lynne Fu, Ralph R. Weichselbaum, Thomas F. Gajewski, Yajun Guo, Yang-Xin Fu. Targeting the tumor microenvironment with interferon- bridges innate and adaptive immune responses. Cancer Cell. 2014 Jan 13;25(1):37-48.
4.Ying He, Jikun Zha, Yamin Wang, Wenhua Liu, Xuanming Yang, and Ping Yu. Tissue damage-associated "danger signals" influence T-cell responses that promote the progression of preneoplasia to cancer. Cancer Res. 2013 Jan 15;73(2):629-39.
5.Xuanming Yang, Xunmin Zhang, Eric Mortenson, Olga Radkevich-Brown, Yang Wang, Yang-Xin Fu. Cetuximab-mediated Tumor Regression Depends on Innate and Adaptive Immune Responses. Molecular Therapy. 2013 Jan;21(1):91-100
6.Xuanming Yang, Eric D Mortenson , Yang-Xin Fu. Targeting and utilizing primary tumors as live vaccines: changing strategies. Cell Mol Immunol. 2011 Nov 21. doi: 10.1038/cmi.2011.49.
7.Qi Da*, Xuanming Yang*, Xiaoqi Li, Youli Xu, Guangxia Gao, Genhong Cheng and Hong Tang. TANK-Binding Kinase 1 Attenuates PTAP-Dependent Retroviral Budding through Targeting Endosomal Sorting Complex Required for Transport-I J Immunol 2011;186;3023-3030 (*, Co-first Author)
8.SaeGwang Park, Zhujun Jiang, Eric D. Mortenson, Liufu Deng, Olga Radkevich-Brown, Xuanming Yang, Husain Sattar, Yang Wang, Nicholas K. Brown, Mark Greene, Yang Liu, Jie Tang, Shengdian Wang, Yang-Xin Fu. The therapeutic effect of anti-HER2/neu antibody depends on both innate and adaptive immunity. Cancer Cell. 2010 Aug 9;18(2):160-70.
9.Xiaoqi Li, Xuanming Yang, Youli Xu, Xuejun Jiang, Fajun Nan, Hong Tang. Troglitazone inhibits cell proliferation by attenuation of Epidermal Growth Factor Receptor Signaling independent of Peroxisome Proliferator-activated Receptor gamma. Cell Research. 2009: 720-732).
10.Jie Zhao, Xuanming Yang, Sogyong Auh, Kwang Dong Kim, Hong Tang and Yang-Xin Fu. Do adaptive immune cells suppress or activate innate immunity? Trends Immunol. 2009 Jan;30(1):8-12.
11.Jie Zhao, Xuanming Yang, Peishuang Du, Hong Tang. T cells regulate initial inflammatory responses during acute infection. Progress in Biochemistry and Biophysics, 2008, 35(2):129-132
12.Jie Zhao*, Kwang Dong Kim*, Xuanming Yang*, Sogyong Auh, Yang-Xin Fu , Hong Tang. Hyper innate responses in neonates lead to increased morbidity and mortality after infection. Proc Natl Acad Sci U S A, 2008, May 27;105 (21):7528-33. (*, Co-first Author)
13.Kwang Dong Kim, Jie Zhao, Sogyong Auh, Xuanming Yang, Peishuang Du, Hong Tang &Yang-Xin Fu. Adaptive immune cells temper initial innate responses. Nature Medicine, 2007, Oct;13 (10):1248-52.

研究成果

主要从事感染与肿瘤的免疫学相关研究,近期侧重于肿瘤免疫学和肿瘤免疫治疗,研究成果发表于Nature Medicine, PNAS, Cancer Cell, Cell Host & Microbe,Molecular Therapy 和 Journal of Immunology 等杂志。已申请一项国家专利,于2011年获北京市科学技术奖一等奖;