魏芳 的个人介绍页
魏芳
魏芳
副研究员
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34207401

个人简历

先后从事肿瘤组织比较基因组学、博莱霉素衍生物抗肿瘤敏感性、基因改变与B/T细胞淋巴瘤形成,以及肿瘤免疫逃逸与治疗等研究方向。留美期间所在实验室在个体化免疫治疗研究与临床实践处于世界领先水平。2013年全职回国后,继续从事CAR和PD-1介导不同类型肿瘤的T细胞过继治疗和ALK蛋白诱癌分子机理研究。已发表第一及共同作者SCI文章20篇,其中包括在PNAS、American J Pathology、Science Translation Medicine、EMBO J、Mol Cell Biol、J Biol Chem、和Cancer Research等杂志;研究结果申请美国专利1项。2014年获浦江人才计划资助。
2013 – 副研究员 上海交通大学 生命科学技术学院盛毓绶细胞与免疫学研究中心
2010 - 2013 研究助理 宾夕法尼亚大学医学院Abramson肿瘤研究所
2008 - 2010 博士后 宾夕法尼亚大学医学院Abramson肿瘤研究所
2005 - 2008 博士后 宾夕法尼亚大学兽医医学院比较肿瘤研究所及动物生物学系
2003 - 2005 研究助理 弗吉尼亚大学化学系
2000 - 2003 博士 中国协和医科大学肿瘤研究所分子肿瘤学国家重点实验室
1997 - 2000 硕士 华中农业大学生命科学院农业微生物国家重点实验室
1994 - 1997 学士 华中农业大学生命科学院

研究方向

肿瘤的发生发展及免疫治疗,慢性病毒及肿瘤的免疫逃逸
1. The biology of PD-1/PD-L1 and its potential application in adoptive T cell therapy when combining with chimeric antigen receptor
2. Mechanisms of oncogene Anaplastic Lymphoma Kinase (ALK)-induced T cell tumorigenesis

发表论文

1. Zhang L*, Zhu C*, Guo Y*, Wei F*, Lu J, Qin J, Banerjee S, Wang J, Shang H, Verma SC, Yuan Z, Robertson ES, Cai Q. Inhibition of KAP1 enhances hypoxia-induced KSHV reactivation through RBP-Jk. J Virol, 88(12):6873-84, 2014 (*co-first author)

2. Wei F, Zhong S, Ma Z, Kong H, Medvec A, Ahmed R, Freeman G, Krogsgaard M, and Riley JR*. Strength of PD-1 Signaling Differentially Affects T Cell Effector Functions. PNAS, 110: e2480-2489, 2013

3. Zhang Q*, Wei F*, Wang H, Liu X, Roy D, Xiong Q, Jiang S, Medvec A, Danet-Desnoyers G, Watt C, Tomczak E, Kalos M, Riley JL*, Wasik M*. A single oncogene NPM-ALK mediates malignant transformation of normal human CD4+ T lymphocytes. Am J Pathol,183(6):1971-80, 2013 (*co-first author)

4. Zhang Q, Wang HY, Wei F, Liu XB, Paterson JC, Roy D, Mihova D, Woetmann A, Ptasznik A, Odum N, Schuster SJ, Marafioti T, Riley J, and Wasik MA*. Cutaneous T-cell lymphoma (CTCL) expresses
immunesuppressive CD80 (B7-1) cell-surface protein in the STAT5-dependent manner. J Immunol, 192:000-000, 2014

5. Pan X, Papasani M, Hao Y, Calamito M, Wei F, Quinn III W, Wang JW, Hodawadekar S, Zaprazna K, Liu HF, Shi Y, Allman D, Cancro M, and Atchison ML*. The YY1 REPO Domain Controls Igk Repertoire, B Cell Development and Co-localizes with Condensin Complex Proteins on the Igκ Locus, EMBO J, 32(8):1168-82, 2013

6. Amarnath S, Mangus CW, Wang JC, Wei F, He A, Kapoor V, Foley JE, Massey PR, Felizardo TC, Riley JL, Levine BL, June CH, Medin JA, Fowler DH*. The PDL1-PD1 axis converts human TH1 cells into regulatory T cells. Sci Transl Med, 3(111):111-120, 2011

7. Wei F, Zaprazna K, Wang J, Atchison ML*. PU.1 can recruit BCL6 to DNA to repress gene expression in germinal center B cells. Mol Cell Biol, 29(17):4612-22, 2009.

8. Wei F, Scholer HR, Atchison ML*. Sumoylation of Oct4 enhances its stability, DNA binding, and transactivation transactivation. J Biol Chem,282(29): 21551-60, 2007.

9. Ma Q, Xu ZD, Schroeder BR, Sun WY, Wei F, Hashimoto S, Konishi K, Leitheise CJ, Hecht SM*. Biochemical evaluation of a 108-member deglycobleomycin library: viability of a selection strategy for identifying bleomycin analogues with altered properties. J Am Chem Soc, 129, 12439-52, 2007.

10. Hodawadekar S, Wei F, Yu D, Thomas-Tikhonenko A, Atchison ML*. Epigenetic histone modifications do not control Igkappa locus contraction and intranuclear localization in cells with dual B cell-macrophage potential. J Immunol, 177(9):6165-71, 2006.

11. Luo ML, Shen XM, Zhang Y, Wei F, Xu X, Cai Y, Zhang X, Sun YT, Zhan QM, Wu M, Wang MR*. Amplification and overexpression of CTTN (EMS1)contribute to the metastasis of esophageal squamous cell carcinoma by promoting cell migration and anoikis resistance. Cancer Res. 66(24):11690-9, 2006.

12. Wei F, Ni J, Wu SS, Liu H, Xu X, Han YL, Cai Y, Zhang JW, Chen XJ, Pang H, Lu N, Ji, Wu M, Wang MR*. Cytogenetic studies of esophageal squamous cell carcinomas in the northern Chinese population by comparative genomic hybridization. Cancer Genet Cytogenet, 138(1): 38-43, 2002.

研究成果

奖励:
魏芳,王明荣等。食管癌相关基因和相关蛋白的研究,中华医学会,中华医学科技奖,二等奖,2003

专利:
Wei F,Riley JR. A method for human T cell immortalization,United States Patent