肖华 的个人介绍页
肖华
肖华
特别研究员
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个人简历

上海交通大学特别研究员,博士生导师。中央组织部“青年千人计划”入选者。2000年毕业于安徽师范大学,获化学学士学位。2007年毕业于中国科学院大连化学物理研究所,获分析化学博士学位。先后在美国加州大学欧文分校、加州大学洛杉矶分校和密西根大学安娜堡分校从事研究工作。在国内外重要学术期刊发表论文近二十篇,参与两本中英文专著章节撰写,申请专利三项,担任多种国际学术期刊论文评阅人。

研究方向

研究方向主要包括分析化学和转化医学、生物分析技术、蛋白质组学和蛋白质翻译后修饰、生物分子的分离分析、生物标志物的发现与验证等,特别是针对重大疾病发展无损伤早期分子诊断技术。

发表论文

1. Xiao, H.*, Zhang, L., Zhou, H., Lee, J.M., Garon, E.B., Wong, D.T.W.* Proteomic analysis of human saliva from lung cancer patients using two-dimensional difference gel electrophoresis and mass spectrometry. Mol. Cell. Proteomics 2012, 11(2):M111.012112. (*Co-corresponding author)
2. Xiao, H.*, Wong, D.T.W.* Proteomic Analysis of Microvesicles in Human Saliva by GeLC-MS/MS. Anal. Chim. Acta 2012, 723, 61-67. (*Co-corresponding author)
3. Xiao, H.*, Wong, D.T.W.* Method Development for Proteome Stabilization in Human Saliva. Anal. Chim. Acta 2012, 722, 63-69. (*Co-corresponding author)
4. Zhang, L.†, Xiao, H.*†, Zhou, H., Santiago, S., Lee, J., Garon, E., Yang, J.P., Brinkmann, O., Yan, X.M., Akin, D., Chia, D., Elashoff, D., Park, N.H., Wong, D.T.W.* Development of Transcriptomic Biomarker Signature in Human Saliva to Detect Lung Cancer. Cell. Mol. Life Sci. 2012, 69, 3341-3350. (†These authors contributed equally to this work; *Co-corresponding author)
5. Elashoff, D., Zhou, H., Reiss, J.K., Wang, J., Xiao, H., Henson, B., Hu, S., Arellano-Garcia, M., Sinha, U.K., Le, A.D., Messadi, D., Wang, M.B., Nabili, V., Lingen, M.W., Morris, D., Randolph, T.W., Feng, Z., Akin, D., Kastratovic, D.A., Chia, D., Abemayor, E., Wong, D.T.W. Pre-Validation of Salivary Biomarkers for Oral Cancer Detection. Cancer Epidemiol Biomarkers Prev. 2012, 21, 664–672
6. Xiao, H., Wong, D.T. Proteomics and its applications for biomarker discovery in human saliva. Bioinformation 2011, 5, 294-296
7. Zhang, L.†, Xiao, H.†, Karlan, S.†, Zhou, H.†, Gross, J., Elashoff, D., Akin, D., Yan, X.M., Chia, D., Karlan, B., Wong, D.T. Discovery and Preclinical Validation of Salivary Transcriptomic and Proteomic Biomarkers for the Non-Invasive Detection of Breast Cancer. PLoS ONE 2010, 5, e15573. (†These authors contributed equally to this work)
8. Zhang, L., Xiao, H., Wong, D.T. Salivary Biomarkers for Clinical Applications. Mol. Diagn. Ther. 2009, 13, 245-259
9. Xiao, H., Yang, L.S., Zou, H.F., Yang, L., Le, X.C. Analysis of oxidized multi-walled carbon nanotubes in single K562 cells by capillary electrophoresis with laser-induced fluorescence. Anal. Bioanal. Chem. 2007, 387, 119-126
10. Xiao, H., Zou, H.F., Pan, C.S., Jiang, X.G., Le, X.C., Yang, L. Quantitative determination of oxidized carbon nanotube probes in yeast by capillary electrophoresis with laser-induced fluorescence detection. Anal. Chim. Acta 2006, 580, 194-199
11. Xiao, H., Li, X., Zou, H.F., Yang, L., Yang, Y.Q., Wang, Y.L., Wang, H.L., Le, X.C. Immunoassay of P-glycoprotein on single cell by capillary electrophoresis with laser induced fluorescence detection. Anal. Chim. Acta 2006, 556, 340-346
12. Xiao, H., Li, X., Zou, H.F., Yang, L., Wang, Y.L., Wang, H.L., Le, X.C. CE-LIF coupled with flow cytometry for high-throughput quantitation of fluorophores in single intact cells. Electrophoresis 2006, 27, 3452-3459
13. Xie, C.H., Hu, J.W., Xiao, H., Su, X.Y., Dong, J., Tian, R.J., He, Z.K., Zou, H.F. Electrochromatographic evaluation of a silica monolith capillary column for separation of basic pharmaceuticals. Electrophoresis 2005, 26, 790-797
14. Fu, H.J., Xie, C.H., Xiao, H., Dong, J., Hu, J.W., Zou, H.F. Monolithic columns with mixed modes of reversed-phase and anion-exchange stationary phase for capillary electrochromatography. J. Chromatogr. A 2004, 1044, 237-244
15. Jin, W.H., Fu, H.J., Huang, X.D., Xiao, H., Zou, H.F. Optimized preparation of poly(styrene-co-divinylbenzene-co-methacrylic acid) monolithic capillary column for capillary electrochromatography. Electrophoresis 2003, 24, 3172-3180

研究成果

专利:
邹汉法,肖华,孔亮。碳纳米管作为载体在抗癌药物转运中的应用,中国专利号200610135092.X,授权号101209349B。
Wong, D.T., Zhang, L., Xiao, H., Zhou, H. Salivary transcriptomic and proteomic biomarkers for breast cancer detection. Patent US 61/303,200 (published, United States Patent Application : 20110212851)
Wong, D.T., Zhang, L., Xiao, H., Zhou, H. Salivary transcriptomic and proteomic biomarkers for lung cancer detection. Patent US 61/303,205 (published, United States Patent, Pub. No.:WO/2011/100483)