白凤武 的个人介绍页
白凤武
白凤武
教授   
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个人简历

教育背景
  博士(2005-2007): Chemical/Biochemical Engineering, University of Waterloo, Canada
  硕士(1985-1988): 大连理工大学, 化学工程(生物化工)专业
  学士(1981-1985): 大连理工大学, 化工机械专业
   
工作经历
  2013.01至今: 上海交通大学生物科学技术学院特聘教授
  1999. 08-2012. 12: 大连理工大学生物科学技术学院教授
  1995. 07-1999. 07: 大连理工大学化工学院副教授
  1990. 07-1995. 06: 大连理工大学化工学院讲师
  1988. 06-1990. 06: 大连理工大学化工学院助教
   其中:1999.09-2000.02: Visiting Scholar, Ohio University, USA
      2002.11-2003.06: Visiting Scholar, University of Waterloo, Canada
      2010.03-2010.12: Visiting Professor, Massachusetts Institute of Technology, USA
   
社会兼职
  1. Member: IUPAC Subcommittee on Biotechnology (www.iupac.org)
  2. Executive Board Member: Asian Federation of Biotechnology (www.afob.org)

学术兼职
  1. Editor:
    Biotechnology Advances (Elsevier, SCI IF 9.65)
  2. Editorial Board Member:
    Biotechnology for Biofuels (Springer, SCI IF 6.09)
    Biotechnology and Bioengineering (Wiley, SCI IF 3.95)
    Journal of Biotechnology (Elsevier, SCI IF 3.05)
    生物工程学报

国际交流
International Conference Organization
1. Co-Chair: Special Forum, the 15th International Biotechnology Symposium (IBS2012), Sept. 16-21, Daegu, Korea
2. Co-Chair: Asian Bioindustry Forum, Asian Congress on Biotechnology 2011, May 11-15, 2011, Shanghai, China
3. Co-Chair: Section 10: Contribution of Chemistry to Biotechnology Based Economy, IBS2010, Sept. 15-19, 2010, Rimini, Italy
4. Co-Chair: the International Scientific Committee and Organizing Committee, the 13th International Biotechnology Symposium (IBS-2008). Oct. 12-17, 2008, Dalian, China
5. Member: the International Advisory Board, the 15th International Biotechnology Symposium (IBS2012), Sept.16-21, Daegu, Korea
6. Member: the International Advisory Board, the First Biotechnology World Congress, Feb. 14-15, 2012, Dubai, UAE
7. Member: the International Scientific Committee, European Science Foundation Conference on Microbes and Industrial Biotechnology, Nov. 21-24, 2010, Bielefeld, Germany
8. Member: the International Advisory Board, the 19th International Enzyme Engineering Conference, Sept. 23-28, 2007, British Columbia, Canada
Invited Lectures
1. Invited Lecture: the 15th International Biotechnology Symposium (IBS2012), Sept. 16-21, 2012, Daegu, Korea
2. Keynote Lecture: Biofuels and Bioenergy in China: Fundamentals, Innovations and Policies at 2011 BIO Pacific Rim Summit, Nov. 22-23, 2011, Kuala Lumpur, Malaysia
3. Keynote Lecture: Self-immobilized cells, concept, research progress and industrial applications at the 1st iBioK (Innovative Bioproduction of Fuels, Bulk and Fine Chemicals from Biomass) Asian Symposium, Dec. 2, 2010, Kobe, Japan
4. Main Lecture: Self-immobilized cells and their potentials in the production of bulk products at the 14th International Biotechnology Symposium (IBS2010), Sept. 14-18, 2010, Rimini, Italy
5. Plenary Lecture at the 5th Moscow International Biotechnology Congress: State of the Art and Prospects of Development. March 16-20, 2009, Moscow, Russia
6. Keynote Lecture at the Session: Chem-Biotech, the 41st IUPAC Congress, August 5-11, 2007, Torino, Italy
7. Keynote Lecture at 2007 KSBB Fall Meeting and International Biotechnology Symposium, October 18-19, 2007, Daegu, Korea
8. Invited Lecture at the 4th Moscow International Biotechnology Congress: State of the Art and Prospects of Development, March 12-16, 2007, Moscow, Russia

研究方向

  长期从事工业生物技术基础研究和创新技术开发,以生物能源产品生产为主要研究方向。系统提出了利用现代生物技术改造或选育目标产物合成性能优良且具有自絮凝能力的菌株,以细胞自絮凝形成颗粒作为细胞固定化方法的自固定化细胞技术的概念,研究开发了工程放大技术。以乙醇发酵为模式体系,采用原生质体融合技术选育发酵性能优良且具有自絮凝能力的酵母菌株,开发了自固定化酵母细胞乙醇连续发酵新技术,并在国家燃料乙醇试点工程建设中得到应用。与现有乙醇发酵技术相比,平均发酵时间显著缩短,发酵罐设备生产强度相应提高;由于酵母细胞以自絮凝颗粒的形态在发酵罐中实现固定化,乙醇精馏后产生废糟液的COD大幅度降低,为燃料乙醇生产源头减废,清洁生产创造了有利条件。先后主持并完成了包括国家自然科学基金、863项目、科技支撑项目及企业委托技术开发项目的研究工作:
  1. 国家“十一五”863项目:自絮凝颗粒酵母高浓度和高强度乙醇发酵新技术;国拨经费:208万
  2. 国家自然科学基金项目:自絮凝颗粒细胞体系在线检测、表征及动力学;资助经费:26万
  3. 国家“十五”重点科技攻关项目:生物能源生产关键技术;国拨经费:200万
  4. 国家“十五”863项目:酒精发酵工艺中基于废糟液直接循环使用的清洁生产技术;国拨经费:90万
  5. 企业委托项目:自絮凝颗粒酵母酒精连续发酵新工艺技术;获得经费:190万
  6. 企业委托项目:自絮凝颗粒酵母乙醇连续发酵新技术建设万吨级规模示范工程;获得经费:200万
  针对以石油资源短缺及其过量开采利用导致生态环境破坏这一重大科学技术和社会问题,开展木质纤维素类生物质资源综合利用生产生物能源和生物基化学品的研究工作,构建如下几个技术平台:1) 生物质资源:开发适宜于非耕地种植且产量高的能源作物, 为生物能源和生物基化学品大规模生产提供原料保障; 2) 生物催化与转化:研究开发纤维素高效酶降解和微生物发酵生产生物能源和生物基化学品创新技术; 3) 系统集成与优化:对原料预处理、纤维素酶解、混合糖发酵、产品分离等单元操作予以集成, 并在系统水平进行优化。目前正在承担以下科研项目的研究工作:
  1. 国家“十二五”863项目:化学品转化关键技术及装备;实施期限:2012-2015;国拨经费:638万
  2. 国家自然科学基金项目:高浓度乙醇连续发酵系统振荡条件下动态动力学;实施期限:2013-
    2016;资助经费:80 万
  3. 国家国际科技合作专项:秸秆原料生产第二代燃料乙醇关键技术合作研究;实施期限:2013-
    2015;预算经费:400万
招生方向
  1. 工业系统生物学及微生物代谢工程
  2. 生物能源产品生产基础研究和创新技术
  3. 环境友好生物技术及清洁生产
  4. 生物反应器工程及放大技术

发表论文

编著学术专著二部,一部由Elsevier出版,另一部由Springer出版;应邀参加多部学术专著的撰写;先后发表论文100多篇,其中50多篇在Metabolic Engineering、Biotechnology for Biofuels、Biotechnology and Bioengineering及Biotechnology Advances等生物技术国际学术期刊上发表。
1. 学术专著(Books)
1) Biotechnology in China III: Biofuels and Bioenergy (Springer, 2012)
2) Industrial Biotechnology and Bulk Commodities (Elsevier, 2011)
2. 专著章节(Book Chapters)
1) Zhao XQ, Zi LH, Bai FW, Lin HL, Hao XM, Yue GJ, Ho NWY. 2012. Bioethanol from lignocellulosic biomass. In Biotechnology in China III: Biofuels and Bioenergy. Advances in Biochemical Engineering/Biotechnology 128: 25-52 (Springer)
2) Wang BW, Shi AQ, Tu R, Zhang XL, Wang QH, Bai FW. 2012. Branched-chain Higher Alcohols. In Biotechnology in China III: Biofuels and Bioenergy. Advances in Biochemical Engineering/Biotechnology 128: 101-118 (Springer)
3) Bai FW, Zhao XQ. 2011. High gravity ethanol fermentations and yeast tolerance. In Microbial stress tolerance for biofuels. Microbiology Monographs 22:117-135 (Springer)
4) Bai FW, Zhao XQ, JF Xu. 2011. Immobilization technology: Cells. In Industrial Biotechnology and Bulk Copmmodities, Comprehensive Biotechnology, Vol 2:477-489 (Elsevier).
3. 代表性论文(Peer review articles)
1) Liu CG, Xue C, Bai FW, Lin YH. Redox potential control and applications in micro-aerobic and anaerobic fermentations. Biotechnology Advances, in press
2) Liu Z, Zhao XQ, Bai FW. Identification of an alkaline tolerant marine-derived Streptomyces strain as a xylanase producer and improvement of its xylanase production by ribosome engineering. Applied Microbiology and Biotechnology, in press.
3) Xue C, Zhao JB, Liu FF, Lu CC, Yang ST, Bai FW. Two-stage in situ gas stripping for enhanced butanol fermentation and energy-saving product recovery. Bioresource Technology, in press.
4) Chun W, Zhao XQ, Guo SL, Alam MA, Bai FW. Efficient cell harvest of marine microalga Nannochloropsis oceanica using bioflocculant produced by Solibacillus silvestris and optimization of bioflocculant production. Bioresource Technology, in press.
5) Guo SL, Zhao XQ, Tang Y, Alam MA, Wan C, Ho SH, Bai FW, Chang JS. 2013. Establishment of an efficient genetic transformation system in Scenedesmus obliquus. Journal of Biotechnology 163: 61-68.
6) Zhao N, Bai Y, Zhao XQ, Bai FW. 2012. Draft genome sequence of the flocculating Zymomonas mobilis strain ZM401. Journal of Bacteriology 194: 7008-9.
7) Liu CG, Wang N, Lin YH, Bai FW. 2012. Very-high-gravity ethanol fermentation by flocculating yeast under redox potential-controlled conditions. Biotechnology for Biofuels 5: 61.
8) Xue C, Zhao JB, Lu CC, Yang ST, Bai FW, Tang IC. 2012. High-titer n-butanol production by Clostridium acetobutylicum JB200 in fed-batch fermentation with intermittent gas stripping. Biotechnology and Bioengineering 109: 2746-56.
9) He LY, Zhao XQ, Bai FW. 2012. Engineering industrial Saccharomyces cerevisiae strain with the FLO1-derivative gene isolated from the flocculating yeast SPSC01 for constitutive flocculation and fuel ethanol production. Applied Energy 100: 33-40.
10) Zhao XQ, Li Q, He LY, Li F, Que WW, Bai FW. 2012. Exploration of a natural reservoir of flocculating genes from various Saccharomyces cerevisiae strains and improved ethanol fermentation using stable genetically engineered flocculating yeast strains. Process Biochemistry 47: 1612-19.
11) He LY, Zhao XQ, Ge XM. Bai FW. 2012. Identification and functional study of a new FLO10-derivative gene from the industrial flocculating yeast SPSC01. Journal of Industrial Microbiology and Biotechnology 39: 1135-40.
12) Xie HB, Shen HW, Gong ZW, Wang Q, Zhao ZK, Bai FW. 2012. Enzymatic hydrolysates of corn stover pretreated by a N-methylpyrrolidone-ionic liquid solution for microbial lipid production. Green Chemistry 14: 1202-10.
13) Zhao XQ, Bai FW. 2012. Zinc and yeast stress tolerance. Journal of Biotechnology 158: 176-83.
14) Li Q, Zhao XQ, Chang AK, Zhang QM, Bai FW. 2012. Ethanol-induced yeast flocculation directed by the promoter of TPS1 encoding trehalose-6-phosphate synthase 1 for efficient ethanol production. Metabolic Engineering 14: 1-8.
15) Yuan WJ, Chang BL, Ren JG, Bai FW, Li YY. 2012. Consolidated bioprocessing strategy for ethanol production from Jerusalem artichoke tubers by K. marxianus under high gravity conditions. Journal of Applied Microbiology 112: 38-44.
16) Liu CG, Lin YH, Bai FW. 2012. Ageing vessel design and optimization for continuous very-high-gravity ethanol fermentation processes. Process Biochemistry 47: 57-61.
17) Liu CG, Lin YH, Bai FW. 2011. A kinetic growth model for Saccharomyces cerevisiae grown under redox potential-controlled very-high-gravity environment. Biochemical Engineering Journal 56: 63-68.
18) Liu CG, Lin YH, Bai FW. 2011. Development of continuous redox potential-controlled fermentation process for ethanol production. Journal of Biotechnology 153: 42-47.
19) Liu CG, Lin YH, Bai FW. 2011. Ageing vessel configuration for continuous redox potential-controlled very-high-gravity fermentation. Journal of Bioscience and Bioengineering 111: 61-66.
20) Yu L, Wang H, Wang L, Bai FW. 2010. Rheological property of self-flocculating yeast suspension. Biochemical Engineering Journal 52: 50-54.
21) Chen HX, Xiu ZL, Bai FW. 2010. Oxidative stress induced in Saccharomyces cerevisiae exposed to dielectric barrier discharge plasma in air at atmospheric pressure. IEEE Transactions on Plasma Science 38: 1885-91.
22) Shen Y, Ge XM, Bai FW. Application of oscillation for efficiency improvement of continuous ethanol fermentation with Saccharomyces cerevisiae under very-high-gravity conditions. Applied Microbiology and Biotechnology 2010, 86: 103-8.
23) Xue C, Zhao XQ, Bai FW. 2010. Effect of the size of yeast flocs and zinc supplementation on continuous ethanol fermentation performance and metabolic flux distribution under very-high-concentration conditions. Biotechnology and Bioengineering 2010, 105: 935-44.
24) Zhao XQ, Bai FW. Mechanism of yeast stress tolerance and its manipulation for efficient ethanol production. Journal of Biotechnology 2009, 144: 23-30.
25) Shen Y, Zhao XQ, Ge XM, Bai FW. Metabolic flux and cell cycle analysis indicating new mechanism underlying process oscillation in continuous ethanol fermentation with Saccharomyces cerevisiae under VHG conditions. Biotechnology Advances 2009, 27: 1118-23.
26) Zhao XQ, Bai FW. Yeast flocculation: New story in fuel ethanol production. Biotechnology Advances 2009, 27: 845-56.
27) Li F, Zhao XQ, Ge XM, Bai FW. An innovative consecutive batch fermentation process for very high gravity ethanol fermentation with self-flocculating yeast. Applied Microbiology and Biotechnology 2009, 84: 1079-86.
28) Bai FW, Ge XM, Anderson WA, Moo-Young M. Parameter oscillation attenuation and mechanism exploration for continuous VHG ethanol fermentation. Biotechnology and Bioengineering 2009, 102: 112-21.
29) Zhao XQ, Xue C, Ge XM, Yuan WJ, Wang JY, Bai FW. Impact of zinc supplementation on the improvement of ethanol tolerance and yield of self-flocculating yeast in continuous ethanol fermentation. Journal of Biotechnology 2009, 39: 55-60.
30) Yuan WJ, Zhao XQ, Ge XM, Bai FW. Ethanol fermentation with Kluyveromyces marxianus from Jerusalem artichoke grown in salina and irrigated with a mixture of seawater and freshwater. Journal of Applied Microbiology 2008, 105: 2076-83.
31) Xue C, Zhao XQ, Yuan WJ, Bai FW. Improving ethanol tolerance of a self-flocculating yeast by optimization of medium composition. World Journal of Microbiol Biotechnology 2008, 24: 2257-61.
32) Bai FW, Anderson WA, Moo-Young M. Ethanol fermentation technologies from sugar and starch feedstocks. Biotechnology Advances 2008, 26: 89–105.
33) Lei JJ, Zhao XQ, Ge XM, Bai FW. Ethanol tolerance and the variation of plasma membrane composition of yeast floc populations with different size distribution. Journal of Biotechnology 2007, 131: 270–75.
34) Li YH, Zhao ZB, Bai FW. High-density cultivation of oleaginous yeast Rhodosporidium toruloides Y4 in fed-batch culture. Enzyme and Microbial Technology 2007, 41: 312–17.
35) Ge XM, Zhang L, Bai FW. Impacts of temperature, pH, divalent cations, sugars and ethanol on the flocculating of SPSC01. Enzyme and Microbial Technology 2006, 39: 783-87.
36) Ge XM, Bai FW. Intrinsic kinetics of continuous ethanol fermentation using a self-flocculating fusant yeast strain SPSC01. Journal of Biotechnology 2006, 124: 363-72.
37) Ge XM, Zhang L, Bai FW. Impact of the floc size distributions on observed substrate uptake and product ffformation rates. Enzyme and Microbial Technology 2006, 39: 289-95.
38) Xu TJ, Zhao XQ, Bai FW. Continuous ethanol production using self-flocculating yeast in a cascade of fermentors. Enzyme and Microbial Technology. 2005, 37: 634-40.
39) Benchapattarapong N, Anderson WA, Bai FW, Moo-Young M. Rheology and hydrodynamic properties of Tolypocladium inflatum fermentation broth and its simulation. Bioprocess and Biosystem Engineering 2005, 27: 239-47.
40) Ge XM, Zhao XQ, Bai FW. Online monitoring and characterization of flocculating yeast cell flocs during continuous ethanol fermentation. Biotechnology and Bioengineering 2005, 90: 523-31.
41) Chen LJ, Xu YL, Bai FW, Anderson WA, Moo-Young M. Observed quasi-steady kinetics of yeast cell growth and ethanol formation under very high gravity fermentation condition. Biotechnology and Biprocess Engineering 2005, 10: 115-21.
42) Bai FW, Chen LJ, Anderson WA, Moo-Young M. Parameter oscillations in very high gravity medium continuous ethanol fermentation and their attenuation on multi-stage packed column bioreactor system. Biotechnology and Bioengineering 2004, 88: 558-66.
43) Bai FW, Chen LJ, Zhang Z, Anderson WA, Moo-Young M. Continuous ethanol production and evaluation of yeast cell lysis and viability loss under very high gravity medium conditions. Journal of Biotechnology 2004, 110: 287-93.
4. 专刊评论(Editorials)
1) Bai FW, Zhang Wei, Zhong JJ. 2010. Preface: Building the bridge between chemistry and biotechnology. Pure and Applied Chemistry 82: 1.
2) Bai FW, Zhang W, Zhong JJ. 2009. Editorial: Special issue on biotechnology for the sustainability of human society. Biotechnology Advances 27: 939.
3) Zhang W, Bai FW, Zhong JJ. 2009. Editorial: Industrial biotechnology: Current status and future development for the sustainability of human society. Journal of Biotechnology 144: 1-2.
4) Zhang W, Bai FW, Zhong JJ. 2009. Editorial: 13th International Biotechnology Symposium and Exhibition. Biotechnology Letters 31: 1313-1314.5) Bai FW. 2009. IBS2008 meeting report: Biotechnology for the sustainability of human society. Chemistry International 31(3), 28-29.

研究成果

专利技术
1. 驯化选育的自絮凝酵母菌株及应用,专利号:ZL 2006 1 0025259.7
2. 燃料乙醇清洁生产技术,专利号:ZL 2006 1 0025258.2
科技奖励
1. UNESCO-MIRCEN Award (2005): The underlying cause for the unsteady state and oscillation in continuous ethanol fermentation using very high gravity medium
2. 2008年教育部科技进步二等奖: 自固定化酵母细胞乙醇连续发酵技术