马钢 的个人介绍页
马钢
马钢
副研究员
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www.bio-x.cn
21

个人简历

上海交通大学副研究员,Bio-X中心发育功能基因组学组副组长,博士,硕导。安徽科技学院学士,长春军需大学硕士,上海交通大学博士。

研究兴趣主要在两个方面:器官发育与信号转导;合成生物学方法研究基因表达及物质代谢调控元器件。目前承担一项国家自然科学基金项目“调节Hedgehog信号蛋白稳定性及影响范围的分子机制的研究”,负责两项973计划子课题:“精源干细胞向皮肤干细胞的分化机制研究”和“集胞藻基因组功能分析及其脂肪酸代谢途径的优化与重建”,一项国家自然基金重点项目的子课题“蛋白转导域内化过程的模拟及应用”。作为指导老师带领交大IGEM队伍参加国际合成生物学竞赛,连续获得金牌和亚洲区总冠军,最佳人工模块设计奖及全球最佳16队等奖项。

研究方向

A-1型短指(趾)症致病基因IHH在骨发育中的功能分析;Wnt,BMP及Hedgehog等信号通路在皮肤及毛囊干细胞发育及相关疾病发生中的作用;合成生物学中特定生物学功能模块的设计与开发,尤其关注调节基因表达和重要生物质代谢途径的元器件的开发与应用。

发表论文

1. Sixia Huang#, Xuming Zhu#, Yanfang Liu, Yixin Tao, Guoyin Feng, Lin He, Xizhi Guo*, Gang Ma*. Wls is Expressed in the Epidermis and Regulates Embryonic Hair Follicle Induction in Mice. PLoS ONE 7(9): e45904. doi:10.1371/journal.pone.0045904.
2. Hui-Yi Kua#, Huijuan Liu#, Wai Fook Leong#, Lili Li, Deyong Jia, Gang Ma, Yuanyu Hu, Xueying Wang, Jenny F. L. Chau, Ye-Guang Chen, Yuji Mishina, Sharon Boast, James Yeh, Li Xia, Guo-Qiang Chen, Lin He, Stephen P. Goff, and Baojie Li*. c-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16 INK4a expression. Nature Cell Biology 2012, 7: 727-737.
3. Gang Ma#, Lili Li#, Yuanyu Hu, Jenny Fung Ling Chau, Bi Jin Au, Deyong Jia, Huijuan Liu, James Yeh, Lin He, Aijun Hao*, and Baojie Li*. Atypical Atm-p53 genetic interaction in osteogenesis is mediated by Smad1 signaling. Journal of Molecular Cell Biology. Journal of Molecular Cell Biology 2012; 4(2):118-20.
4. Ma G, Yu J, Xiao Y, Chan D, Gao B*, Hu J, He Y, Guo S, Zhou J, Zhang L, Gao L, Zhang W, Kang Y, Cheah KS, Feng G, Guo X, Wang Y, Zhou CZ, He L*. INDIAN HEDGEHOG mutations causing brachydactyly type A1 impair Hedgehog signal transduction at multiple levels. Cell Research 2011; 21(9):1343-57.
5. Gao B#, Hu J#, Stricker S, Cheung M, Ma G, Law KF, Witte F, Briscoe J, Mundlos S, He L*, Cheah KS, Chan D*. A mutation in Ihh that causes digit abnormalities alters its signalling capacity and range. Nature 2009; 458, 1196-1200.
6. Ma G, Xiao Y, He L*. Recent progress in the study of Hedgehog signaling. Journal of Genetics and Genomics 2008; 35(3): 129-137.
7. Ma G#, He Z#, Fang W, Tang W, Huang K, Li Z, He G, Xu Y, Feng G, Zheng T, Zhou J, He L*, Shi Y*. The Ser9Gly Polymorphism of the Dopamine D3 Receptor Gene and Risk of Schizophrenia: An Association Study and a large Meta-Analysis. Schizophrenia research 2008; 101:26-35.
8. Ma G#, Shi Y#*, Tang W, He Z, Huang K, Li Z, He G, Feng G, Li H, He L*. An association study between the genetic polymorphisms within TBX1 and schizophrenia in the Chinese population. Neurosci Lett 2007; 425(3):146-150.

#并列第一作者 *通讯作者

研究成果

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