唐鸿志 的个人介绍页
唐鸿志
唐鸿志
教授
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个人简历

上海交通大学生命科学技术学院/微生物代谢国家重点实验室教授、博士生导师。2012年12月-2013年12月美国麻省理工学院访问学者。曾获得国家自然基金委“优秀青年基金”(2014年)、上海市“青年科技启明星”(2013年)、上海市“晨光学者”(2010年)、上海交通大学“晨星学者”A类(2014年)、上海交通大学“青年岗位能手”(2012年)、上海交通大学“十佳优秀班主任”(2011年)。2013年获得上海市“明治乳业生命科学奖”和“益海嘉里青年教师奖”。主持多项国家如自然基金委(如优秀青年、面上、青年)、教育部(如新教师基金)、上海市科技启明星等,并作为研究骨干参与了国家973、863等。已发表SCI论文59篇(第一/通讯作者23篇),他引600次以上。如以第一/通讯作者在遗传学领域主流期刊PLoS. Genet.,微生物学领域顶级期刊Mol. Microbiol.(2篇)、微生物学主流期刊Appl. Environ. Microbiol.(4篇)、J. Bacteriol.(6篇)、生物化学领域主流期刊J. Biol. Chem.等期刊发表。担任Journal of Food Processing & Beverages、American Journal of Experimental Biology、Scholarena Journal of Biotechnology杂志编委。

研究方向

1. 微生物降解含氮杂环污染物-尼古丁的分子机理研究
2. 微生物降解含氧杂环污染物-二苯并呋喃的分子机理研究
3. 微生物嗜热、嗜盐、嗜酸机理
4. 微生物高效合成D-乳酸的研究

发表论文

1. Liu Y. P., Tang H. Z*., Lin Z. L., and Xu P*. 2015. Mechanisms of acid tolerance in bacteria and prospects in biotechnology and bioremediation. Biotechnol. Adv. un 6. pii: S0734-9750(15)30010-0. doi: 10.1016/j.biotechadv.2015.06.001. [Epub ahead of print].
2. Yu H., Tang H. Z*., Li Y. Y., and Xu P*. 2015. Novel genes coding for a molybdenum-containing nicotine hydroxylase in the VPP nicotine degradation pathway. Appl. Environ. Microbiol. doi:10.1128/AEM.02253-15. Epub ahead of print.
3. Yu H†., Tang H. Z†*. Zhu X. Y., Li Y. Y., and Xu P*. 2015. Molecular mechanism of nicotine degradation by a newly isolated strain Ochrobactrum sp. SJY1. Appl. Environ. Microbiol. 81(1):272-281. (*, Corresponding author) († these authors contributed equally to this work)
4. Ding J. M., Yu T. T., Han N. Y., Yu J. L., Li J. J., Yang Y. J., Tang X. H., Xu B., Zhou J. P., Tang H. Z*., and Huang Z. X*. 2015. Identification and characterization of a new 7-aminocephalosporanic acid deacetylase from thermophilic bacterium Alicyclobacillus tengchongensis. J. Bacteriol. Accepted on Oct. 15th.
5. Wang W. W., Xu P., and Tang H. Z*. 2015. Sustainable production of valuable compound 3-succinoyl-pyridine by genetically engineering Pseudomonas putida using the tobacco waste. Sci. Rep. Accepted on Oct. 14th.
6. Jiang Y., Tang H. Z*., Wu G., and Xu P. 2015. Functional identification of a novel gene, moaE, for 3-succinoylpyridine degradation in Pseudomonas putida S16. Sci. Rep. 5:13464.
7. Huang L., Hu H. Y., Tang H. Z*., Liu Y. D., Xu P., Shi J., Lin K. F., Luo Q. S., and Cui C. Z*. 2015. Identification and characterization of a novel gentisate 1,2-dioxygenase gene from a Halophilic Martelella strain. Sci. Rep. 5:14307.
8. Yao Y. X†., Tang H. Z†., Su F., and Xu P.* 2015. Comparative genome analysis reveals the molecular basis of nicotine degradation and survival capacities of Arthrobacter. Sci. Rep. 5:8642.
9. Qu Y. Y*., Liu Z. Y., Shen W. L., Li S. Z., Tang H. Z*., and Xu P. 2015. Genome sequence of an indigoids-producing strain, Pseudomonas sp. PI1. Genome A. 3(3):e00622-15.
10. Jiang Y., Qu Y. Y., Xu P., Tang H. Z*. 2015. Genome sequence of a versatile aromatic hydrocarbon-degrading bacterium, Arthrobacter sp. W1. Genome A. 3(2):e00387-15.
11. Ma Q., Qu Y. Y*., Zhang Z. J., Li P. P., Tang H. Z*. 2015. Genome sequence of an efficient indole degrading bacterium Cupriavidus sp. IDO with 1 potential polyhydroxyalkanoate production applications. Genome A. 3(2):e00102-15.
12. Yu H., Li Y. Y., Tang H. Z*. and Xu, P. 2014. Genome sequence of a newly isolated nicotine-degrading bacterium, Ochrobactrum sp. SJY1. Genome A. 2(4):e00720-14.
13. Liu Y. H†., Wang L. J†., Huang K. M., Wang W. W., Nie X. L., Jiang Y., Li P. P., Liu S. S., Xu P., and Tang H. Z*. 2014. Physiological and biochemical characterization of a novel nicotine degrading bacterium Pseudomonas geniculata N1. PLoS ONE 9 (1), e84399.
14. Cui C. Z., Li P. P., Liu G., Tang H. Z*., Lin K. F., Luo Q. S., Liu S. S., Xu P., and Liu Y. D*. 2014. Genome sequence of Martelella sp. strain AD-3, a moderately halophilic polycyclic aromatic hydrocarbons-degrading bacterium. Genome A. 2(1):e01189-13.
15. Huang K. M., Ni J., Xu K., Tang H. Z*., Tao F., and Xu P. 2014. Genome sequence of Sporolactobacillus terrae DSM 11697, the type strain of the species. Genome A. 2(3):e00465-14.
16. Wu G†., Chen D. D†., Tang H. Z†., Ren Y. L., Chen Q. H., Lv Y., Zhang Z. Y., Zhao Y. L*., Yao Y. X., and Xu P.* 2014. Structural insights into the specific recognition of N-heterocycle biodenitrogenation-derived substrates by microbial amide hydrolases. Mol. Microbiol., 91(5):1009-1021.
17. Wang L. J., Tang H. Z., Yu H., Yao Y. X., and Xu P.* 2014. An unusual repressor controls the expression of a crucial nicotine-degrading gene cluster in Pseudomonas putida S16. Mol. Microbiol., 91(6):1252-1269.
18. Tang H. Z., Wang L. J†., Wang W. W†., Yu H†., Zhang K. Z., Yao Y. X., and Xu P.* 2013. Systematic unraveling of the unsolved pathway of nicotine degradation in Pseudomonas. PLoS Genet. 9(10):e1003923.
19. Yang W. W., Tang H. Z*., Ni J., Wu Q. L., Hua D. L., Tao F., and Xu P.* 2013(June). Characterization of two Streptomyces enzymes converting ferulic acid to vanillin. PLoS ONE 8(6):e67339.
20. Chen D. D†., Tang H. Z†., Lv Y., Zhang Z.Y., Shen K. L., Lin K., Zhao Y. L., Wu G*., and Xu P* 2013(Mar.). Structural and computational studies of the maleate isomerase from Pseudomonas putida S16 reveal a breathing motion wrapping the substrate inside. Mol. Microbiol., 87(6):1237-1244.
21. Qu Y. Y†., Zhang X. W†., Yu H†., Tang H. Z†*., Shen E., Zhou H., Ma Q., Cao X.Y., Zhou J. T., and Xu P.* 2013(Jan). Genome sequence of Sphingomonas xenophaga QYY, an anthraquinones degrading strain. Genome A. 1(1):e00031-12.
22. Kong C. L†., Wang L. J†., Li P. P†., Qu Y. Y*., Tang H. Z*., Wang J. W., Zhou H., Ma Q., Zhou J. T., and Xu P. 2013. Genome sequence of Dyella ginsengisoli LA-4, an efficient degrader of aromatic compounds. Genome A. 1(6):e00961-13.
23. Tang H. Z*., Li J., Hu H. Y., and Xu P. 2012 (Dec.). A newly isolated Stenotrophomonas sp. strain hydrolyzes acetamiprid, a synthetic insecticide for controlling insects. Process Biochem. 47(12): 1820-1825.
24. Yao Y. X†., Tang H. Z†*., Ren H. X., Yu H., Wang L. J., and Xu P.* 2012(Oct.). Genome sequence of a nicotine-degrading strain of Arthrobacter. J. Bacteriol. 194: 5714-5715.
25. Ma Q†., Qu Y.Y†*., Tang H. Z†., Yu H†., Ma F., Shi S.N., Zhang X.W., Zhou H., Zhou J.T., and Xu P.* 2012(Aug.). Genome sequence of a novel indigo-producing strain, Pseudomonas monteilii QM. J. Bacteriol. 194:4459-4460.
26. Tang H. Z†., Yao Y. X†., Wang L. J., Yu H., Ren Y. L., Wu G., and Xu P.* 2012(Apr.). Genomic analysis of Pseudomonas putida: genes in a genome island are crucial for nicotine degradation. Sci. Rep. 2, 377.
27. Tang H. Z., Yao Y. X†., Zhang D. K†., Meng X. Z†., Wang L. J†., Yu H†., Ma L. Y., and Xu P., 2011(Nov.). A Novel NADH-dependent and FAD-containing hydroxylase is crucial for nicotine degradation by Pseudomonas putida. J. Biol. Chem. 286(45):39179-39187.
28. Tang H. Z†., Yu H†., Tai C†., Huang K. M., Liu Y. H., Wang L. J., Yao Y. X., Wu G., and Xu P.* 2012(Jul.). Genome sequence of a novel nicotine-degrading strain, Pseudomonas geniculata N1. J. Bacteriol. 194(13): 3553-3554.
29. Tang H. Z†., Yu H†., Li Q. G†., Wang X. Y., Gai Z. H., Yin G. B., Su F., Tao F., Ma C. Q., and Xu P.* 2011(Dec.). Genome sequence of the Pseudomonas putida strain B6-2, a super degrader of polycyclic aromatic hydrocarbons and dioxin-like compounds. J. Bacteriol. 193(23):6789-6790.
30. Yu H†., Tang H. Z†., Wang L. J., Yao Y. X., Wu G., and Xu P.* 2011(Oct.). Complete genome sequence of nicotine-degrading Pseudomonas putida strain S16. J. Bacteriol. 193(19): 5541-5542.
31. Tang H. Z., Wang L. J., Meng X. Z., Ma L. Y., Wang S. N., He X. F., Wu G., and Xu P.* 2009(Feb.). Novel nicotine oxidoreductase-encoding gene involved in nicotine degradation by Pseudomonas putida strain S16. Appl. Environ. Microbiol. 75(3): 772-778.
32. Tang H. Z., Wang S. N., Ma L. Y., Meng X. Z., Deng Z. X., Zhang D. K., Ma C. Q., and Xu P.* 2008(Mar.). A novel gene encoding 6-hydroxy-3-succinoylpyridine hydroxylase in nicotine degradation by Pseudomonas putida strain S16. Appl. Environ. Microbiol. 74(5): 1567-1574.

研究成果

烟草加工和烟草消费过程中产生大量富含尼古丁等烟碱类化合物的固体和液体废弃物,严重污染大气,水体与土壤环境。恶臭假单胞菌S16能够以尼古丁为唯一碳氮源并高效分解代谢尼古丁,实现变废为宝。研究首次从分子水平全面、系统的阐明了困惑科学家近60年的假单胞菌代谢尼古丁的吡咯代谢主途径的机制,发现该途径与人体代谢尼古丁的2'羟基化途径类似,将为难降解有机污染物微生物分解代谢机制的解析和相关生物资源有效利用提供指导和帮助。