特聘教授
肥胖和伴随的糖尿病成为繁荣时代的重要灾难之一。我们尝试从人类进化的角度,研究人类基因组变化,生活方式的改变等对肥胖和糖尿病形成的调控作用。
间充质干细胞的衰老是肌体许多衰老疾病的细胞学基础。清理衰老细胞(senolysis)可以作为治疗衰老相关疾病的重要策略。我们研究发现Foxp1基因调控骨髓间充质干细胞的衰老,这有可能作为调控衰老疾病的重要靶点之一。
以基因敲除小鼠为模型,研究成骨细胞和破骨细胞分化,骨质重塑的调控过程,分析骨质疏松,骨关节炎等退行性疾病的病理机制,为治疗这些疾病探寻药物靶点。
Foxp2 regulates anatomical features that may be relevant for vocal behavior and bipedal locomotion.
Foxp1 controls cell fate commitment and senescence of mesenchymal stem cells during skeletal aging
Bone marrow fibrosis with fibrocytic and immunoregulatory responses induced by β-catenin activation in osteoprogenitors
Ablation of Wntless in endosteal niches impairs lymphopoiesis rather than HSC maintenance.
Ectodermal Wnt signaling regulates abdominal myogenesis during ventral body wall development.
Osteoblastic Wnts differentially regulate bone remodeling and the maintenance of bone marrow mesenchymal stem cells.
Wnts-mediated reciprocal regulation between cartilage and bone development during endochondral ossification.