上海交通大学特别研究员，博士生导师。2009年1月获韩国科学技术院(KAIST) 化学与生物分子工程博士学位，之后在韩国KAIST及美国Tufts大学从事博士后研究，于2012年9月加入上海交通大学，并被授予上海高校特聘教授（东方学者）称号，且入选上海市浦江人才计划（A类）。

       主要研究先进功能材料的设计与微生物合成，在PNAS、Advanced Materials、Biomacromolecules等国际期刊发表SCI研究论文42篇，代表性人工蜘蛛丝研究成果被Nature Chemical Biology和麻省理工学院出版的Technology Review以“新闻和观点”和专题等形式作了评论和推介，获得美国、澳大利亚等国家发明专利授权10余项，应邀在包括2017年国际合成生物学大会、2015年哥本哈根生物科学会议等有影响的国际会议作学术报告10余次，并担任国际期刊Biotechnology Journal及ACS Biomaterials Science&Engineering编委。

• 先进材料的仿生合成
• 新型智能生物材料的设计与合成
• 蛋白生物材料的高效生物制造及应用

1. Zhou Z^†, Zhang S^†, Marelli B^*, Xia XX*, Tao TH^*. Engineering the future of silk materials through adaptable modification and advanced manufacturing. Adv Mater, 2018, DOI: 10.1002/adma.201706983.
2. Jiang J^†, Zhang S^†, Qian Z, Qin N, Song W, Sun L, Zhou Z, Shi Z, Chen L, Li X, Mao Y, Kaplan DL, Gilbert Corder SN, Chen X, Liu M, Omenetto FG, Xia XX^*, Tao TH^*. Protein bricks: 2D and 3D bio-nanostructures with shape and function on demand. Adv Mater, 2018, DOI: 10.1002/adma.201705919 (Selected as inside back cover).
3. Chen XF, Xia XX, Lee SY, Qian ZG^*. Engineering tunable biosensors for monitoring putrescine in Escherichia coli. Biotechnol Bioeng, 2018, 115(4): 1014-1027.
4. Yu JL, Xia XX, Zhong JJ^*, Qian ZG^*. Enhanced production of C5 dicarboxylic acids by aerobic-anaerobic shift in fermentation of engineered Escherichia coli. Process Biochem, 2017, 62: 53-58.
5. Jiang H, Xia XX, Feng Y, Zhong JJ, Qian ZG^*. Development of a robust system for high-throughput colorimetric assay of diverse amino acid decarboxylases. Process Biochem, 2017, 60: 27-34.
6. Yu JL, Xia XX, Zhong JJ^*, Qian ZG^*. A novel synthetic pathway for glutarate production in recombinant Escherichia coli. Process Biochem, 2017, 59: 167-171.
7. Huang SC^†, Qian ZG^†, Dan AH, Hu X, Zhou ML, Xia XX^*. Rational design and hierarchical assembly of a genetically engineered resilin-slik copolymer results in stiff hydrogels. ACS Biomater Sci Eng, 2017, 3(8): 1576-1585.
8. Qiao X, Qian Z, Li J, Sun H, Han Y, Xia XX, Zhou J, Wang C, Wang Y^*, Wang C^*. Synthetic engineering spider silk fiber as implantable optical waveguides for low-loss light guiding. ACS Appl Mater Interfaces, 2017, 9(17): 14665-14676.
9. Chen L, Zhou ML, Qian ZG, Kaplan DL, Xia XX^*. Fabrication of protein films from genetically engineered silk-elastin-like proteins by controlled cross-linking. ACS Biomater Sci Eng, 2017, 3(3): 335-341.
10. Zhou ML, Qian ZG, Chen L, Kaplan DL, Xia XX^*. Rationally designed redox-sensitive protein hydrogels with tunable mechanical properties. Biomacromolecules, 2016, 17(11): 3508-3515.
11. Peng Q^†, Zhang Y^†*, Lu L, Shao H, Qin K, Hu X, Xia XX*. Recombinant spider silk from aqueous solutions via a bio-inspired microfluidic chip. Sci Rep, 2016, 6: 36473.
12. Qin N^†, Zhang S^†, Jiang J, Corder SG, Qian Z, Zhou Z, Lee W, Liu K, Wang X, Li X, Shi Z, Mao Y, Bechtel HA, Martin MC, Xia XX, Marelli B, Kaplan DL, Omenetto FG^*, Liu M^*, Tao TH^*. Nanoscale probing of electron-regulated structural transitions in silk proteins by near-field IR imaging and nano-spectroscopy. Nat Commun, 2016, 7: 13079.
13. Huang W, Tarakanova A, Dinjaski N, Wang Q, Xia XX, Chen Y, Wong JY, Buehler MJ, Kaplan DL^*. Design of multistimuli responsive hydrogels using integrated modeling and genetically engineered silk-elastin-like-proteins. Adv Funct Mater, 2016, 26(23): 4113-4123.
14. Yang YX, Qian ZG, Zhong JJ^*, Xia XX^*. Hyper-production of large proteins of spider dragline silk MaSp2 by Escherichia coli via synthetic biology approach. Process Biochem, 2016, 51(4): 484-490. (Editors’ Choice paper)
15. Qian ZG^†, Zhou ML^†, Song WW, Xia XX*. Dual thermosensitive hydrogels assembled from the conserved C-terminal domain of spider dragline silk. Biomacromolecules, 2015, 16(11): 3704-3711.
16. Qi K, Xia XX, Zhong JJ^*. Enhanced anti-oxidative activity and lignocellulosic ethanol production by biotin addition to medium in Pichia guilliermondii fermentation. Bioresource Technol, 2015, 189: 36-43.
17. Yu JL, Xia XX, Zhong JJ^*, Qian ZG^*. Direct biosynthesis of adipic acid from a synthetic pathway in recombinant Escherichia coli. Biotechnol Bioeng, 2014, 111(12): 2580-2586.
18. Xu YN, Xia XX, Zhong JJ^*. Induction of ganoderic acid biosynthesis by Mn²⁺ in static liquid cultivation of Ganoderma lucidum. Biotechnol Bioeng, 2014, 111(11) :2358-2365.
19. Qi K, Zhong JJ^*, Xia XX^*. Triggering respirofermentative metabolism in the Crabtree-negative yeast Pichia guilliermondii by disrupting the CAT8 Gene. Appl Environ Microbiol, 2014, 80(13): 3879-3887.
20. Xia X, Lin S, Xia XX, Cong FS, Zhong JJ^*. Significance of agitation induced shear stress on mycelium morphology and lavendamycin production by engineered Streptomyces flocculus. Appl Microbiol Biotechnol, 2014, 98(10): 4399-4407.
21. Wang Q^†, Xia XX^†, Huang W, Lin Y, Xu Q, Kaplan DL^*. High throughput screening of dynamic silk-elastin-like protein biomaterials. Adv Funct Mater, 2014, 24(27): 4303-4310.
22. Lin Y^†, Xia XX^†, Wang M^†, Wang Q, An B, Tao H, Xu Q, Kaplan DL^*. Genetically programmable thermoresponsive plasmonic gold/silk-elastin protein core/shell nanoparticles. Langmuir, 2014, 30(15): 4406-4414.
23. Xia XX^†, Wang M^†, Lin Y, Xu Q, Kaplan DL^*. Hydrophobic drug-triggered self-assembly of nanoparticles from silk-elastin-like protein polymers for drug delivery. Biomacromolecules, 2014, 15(3): 908-914.
24. Dou Y, Xiao JH^*, Xia XX, Zhong JJ^*. Effect of oxygen supply on biomass and helvolic acid production in submerged fermentation of Cordyceps taii. Biochem Eng J, 2013, 81: 73-79.
25. Hu X, Tang-Schomer MD, Huang W, Xia XX, Weiss AS, Kaplan DL^*. Charge-tunable autoclaved silk-tropoelastin protein alloys that control neuron cell responses. Adv Funct Mater, 2013, 23(31): 3875-3884.
26. Lin Y, Xia XX, Shang K, Elia R, Huang W, Cebe P, Leisk G, Omenetto F, Kaplan DL^*. Tuning chemical and physical cross-links in silk electrogels for morphological analysis and mechanical reinforcement. Biomacromolecules, 2013, 14(8): 2629-2635.
27. Xu YN, Xia XX, Zhong JJ^*. Induced effect of Na⁺ on ganoderic acid biosynthesis in static liquid culture of Ganoderma lucidum via calcineurin signal transduction. Biotechnol Bioeng, 2013, 110(7): 1913-1923 (Spotlight paper, see DOI: 10.1002/bit.24670).
28. Fan C, Qi K, Xia XX^*, Zhong JJ^*. Efficient ethanol production from corncob residues by repeated fermentation of an adapted yeast. Bioresource Technol, 2013, 136: 309-315.
29. Sun Z, Qin G, Xia XX, Mark, CG, Omenetto, F, Kaplan DL^*. Photoresponsive retinal-modified silk-elastin copolymer. J Am Chem Soc, 2013, 135 (9): 3675-3679.
30. An B, DesRochers TM, Qin G, Xia XX, Thiagarajan G, Brodsky B, Kaplan DL^*. The influence of specific binding of collagen-silk chimeras to silk biomaterials on hMSC behavior. Biomaterials, 2013, 34(2): 402-412.
31. Yoon SH, Han MJ, Jeong H, Lee CH, Xia XX, Lee DH, Shim JH, Lee SY, Oh TK, Kim JF^*. Comparative multi-omics systems analysis of Escherichia coli strains B and K-12. Genome Biol, 2012, 13(5): 1-13.
32. Hu X, Park SH, Gil ES, Xia XX, Weiss AS, Kaplan DL^*. The influence of elasticity and surface roughness on myogenic and osteogenic-differentiation of cells on silk-elastin biomaterials. Biomaterials, 2011, 32(34): 8979-8989.
33. Xia XX, Xu Q, Hu X, Qin G, Kaplan DL^*. Tunable self-assembly of genetically engineered silk-elastin protein polymers. Biomacromolecules, 2011, 12(11): 3844-3850.
34. Xia XX, Qian ZG, Lee SY^*. Comparative proteomic and genetic analyses reveal unidentified mutations in Escherichia coli XL1-Blue and DH5α. FEMS Microbiol Lett, 2011, 314(2): 119-124.
35. Qian ZG, Xia XX, Lee SY^*. Metabolic engineering of Escherichia coli for the production of cadaverine: A five carbon diamine. Biotechnol Bioeng, 2011, 108(1): 93-103.
36. Xia XX^†, Qian ZG^†, Ki CS, Park YH, Kaplan DL, Lee SY^*. Native-sized recombinant spider silk protein produced in metabolically engineered Escherichia coli results in a strong fiber. Proc Natl Acad Sci USA, 2010, 107(32): 14059-14063.

             News and Views in Nature Chemical Biology (Linke WA. Biomaterials: Spider strength and stretchability. Nature                         Chemical Biology 6:702-703; October 2010)

             Featured by MIT Technology Review (3 August 2010)

37. Qian ZG, Xia XX, Lee SY^*. Metabolic engineering of Escherichia coli for the production of putrescine: A four carbon diamine. Biotechnol Bioeng, 2009, 104(4): 651-662.

Editors' Choice, Journal cover paper; Wiley-Blackwell Press Release ‘Pioneering research succeeds in producing industrially vital chemical through engineered bacteria’ (27 Aug. 2009); Nature Research Highlight ‘Bacterial factories’ (Nature 461, 14-15; 3 September 2009); BTJ-FORUM ‘Metabolic engineering of E. coli’ (Biotechnology Journal, 2009, 4: 1376).

38. Qian ZG^†, Xia XX^†, Lee SY^*. Proteome-based identification of fusion partner for high-level extracellular production of recombinant proteins in Escherichia coli. Biotechnol Bioeng, 2008, 101(3): 587-601.

Spotlight ‘A proteome-based approach to identifying fusion partner for recombinant protein excretion’ (Biotechnology and Bioengineering DOI: 10.1002/bit.22096).

39. Xia XX, Han MJ, Lee SY^*, Yoo JS. Comparison of the extracellular proteomes of Escherichia coli B and K-12 strains during high cell density cultivation. Proteomics, 2008, 8(1): 2089-2103.
40. Shen YL^*, Zhang Y, Sun AY, Xia XX, Wei DZ^*, Yang SL. High-level production of soluble tumor necrosis factor-related apoptosis-inducing ligand (Apo2L/TRAIL) in high-density cultivation of recombinant Escherichia coli using a combined feeding strategy. Biotechnol Lett, 2004, 26: 981-984.
41. Xia XX, Shen YL^*, Wei DZ^*. Purification and characterization of recombinant sTRAIL expressed in Escherichia coli. Acta Bioch Bioph Sin, 2004, 36 (2): 118-122.
42. Shen YL^*, Xia XX, Zhang Y, Liu JW, Wei DZ^*, Yang SL. Refolding and purification of Apo2L/TRAIL produced as inclusion bodies in high-cell-density cultures of recombinant Escherichia coli. Biotechnol Lett, 2003, 25(24): 2097-2101.