教授/长聘副教授
多杀菌素(杀虫)、红霉素(抗细菌)、泰乐菌素(抗细菌)、纳他霉素(抗真菌)等抗生素大品种生产菌株的高产育种和理性改良；新抗生素的高产菌种研制。
链霉菌、拟无枝酸菌和糖多孢菌等细菌底盘的基因组编辑与人工进化。
沉默的天然产物基因簇的高效激活；新结构、新活性化合物的分离鉴定；微生物天然产物生物合成途径的解析；化合物的组合生物合成等。
Genome-wide mutagenesis links multiple metabolic pathways with actinorhodin production in Streptomyces coelicolor. Xu Z*, Li Y, Wang Y, Deng Z, Tao M*. Appl Environ Microbiol, March 2019, 85(7). e03005-18. doi: 10.1128/AEM.03005-18.
Engineered Streptomyces lividans strains for optimal identification and expression of cryptic biosynthetic gene clusters. Peng Q, Gao G, Lü J, Long Q, Chen X, Zhang F, Xu M, Liu K, Wang Y, Deng Z, Li Z*, Tao M*. Front Microbiol. Dec. 2018, 9:3042. doi: 10.3389/fmicb.2018.03042.
Biosynthesis of tropolones in Streptomyces spp: interweaving biosynthesis and degradation of phenylacetic acid and hydroxylations on tropone ring. Chen X, Xu M, Lü J, …Lin S, Deng Z, Tao M*. Appl Environ Microbiol, 2018, doi: 10.1128/AEM.00349-18.
Formation of an angular aromatic polyketide from a linear anthrene precursor via oxidative rearrangement. Gao G, Liu X, Xu M, … Jiang M,* Lin S.* Tao M*. Cell Chem Biol, 2017, 24:881-891.
Iteratively improving natamycin production in Streptomyces gilvosporeus by a large operon-reporter based strategy. Wang Y, Tao Z, Zheng H, Zhang F, Long Q, Deng Z, Tao M*. Metab Eng, 2016, 38:418-426.
Functional genome mining for metabolites encoded by large gene clusters through heterologous expression of a whole-genome bacterial artificial chromosome library in Streptomyces spp. Xu M, Wang Y, Zhao Z, … Pang X, Deng Z, Tao M*. Appl Environ Microbiol, 2016, 82:5795-5805.
Hybrubins: bipyrrole tetramic acids obtained by crosstalk between a truncated undecylprodigiosin pathway and heterologous tetramic acid biosynthetic genes. Zhao Z, Shi T, Xu M, … Deng Z, Pang X*, Tao M*. Org Lett, 2016, 18:572-575.
A cellulose synthase-like protein involved in hyphal tip growth and morphological differentiation in Streptomyces. Xu H, Chater K F, Deng Z, and Tao M*. Journal of Bacteriology, 2008, 190(14): 4971-4978.
A genetic and bioinformatic analysis of Streptomyces coelicolor genes containing TTA codons, possible targets for regulation by a developmentally significant tRNA. Li W, Wu J, Tao W, Zhao C, Wang Y, He X, Chandra G, Zhou X, Deng Z, Chater K F, and Tao M*. FEMS Microbiology Letters, 2007, 266(1): 20-28.
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