姓名: Ilya Vinnikov
Keywords: neuroscience, microRNA, metabolism, neurodegeneration, obesity, circadian, transcription regulation and epigenetic control in eukaryotes, mouse.
Chronic metabolic and neurodegenerative syndromes, such as diabetes mellitus, obesity or Parkinson’s disease, represent a growing epidemic, especially in the constantly aging western populations. These currently incurable complex traits result from a failure in the interplay of environmental factors, humoral signals, extra- and intracellular enzymatic cascades, genetic and epigenetic signals in the central nervous system and in the periphery. Physiological and pathophysiological mechanisms involved in these processes require intensive research to provide the patients with novel therapeutic strategies. The lab has a strong interest in studying the role of distinct neuronal population-specific non-coding RNAs in chronic complex traits disorders. In perspective, the integration of expression and functional data from mouse and patient brain samples will provide novel insights for future genome wide association studies aiming to identify genetic variants within non-coding RNA genes and/or within the genes influenced by these RNA species aiming to decipher the mechanisms involved in metabolic and neurodegenerative disorders.
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